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8 papers found.
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Airway management in pre-hospital critical care: a review of the evidence for a ‘top five’ research priority

The conduct and benefit of pre-hospital advanced airway management and pre-hospital emergency anaesthesia have been widely debated for many years. In 2011, prehospital advanced airway management was identified as a ‘top five’ in physician-provided pre-hospital critical care. This article summarises the evidence for and against this intervention since 2011 and attempts to address...

Targeted sequencing of BRCA1 and BRCA2 across a large unselected breast cancer cohort suggests that one-third of mutations are somatic

Background A mutation found in the BRCA1 or BRCA2 gene of a breast tumor could be either germline or somatically acquired. The prevalence of somatic BRCA1/2 mutations and the ratio between somatic and germline BRCA1/2 mutations in unselected breast cancer patients are currently unclear.

A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis

Aims/hypothesis The enzyme hormone-sensitive lipase (HSL) is produced and is active in pancreatic beta cells. Because lipids are known to play a crucial role in normal control of insulin release and in the deterioration of beta cell function, as observed in type 2 diabetes, actions of HSL in beta cells may be critical. This notion has been addressed in different lines of HSL...

The role of matrix metalloproteinase activity in the maturation of human capillary endothelial cells in vitro

in vitro. MATERIALS AND METHODS Antibodies used in this study Rabbit anti-human collagen type XVIII (anti-all hu XVIII, QH48.18) was generously provided by Dr M. Rehn and Dr T. Pihlajaniemi

Induced repatterning of type XVIII collagen expression in ureter bud from kidney to lung type: association with sonic hedgehog and ectopic surfactant protein C

indicated under Results. The ELQ and Q36.4 antibodies against type XVIII collagen have been described elsewhere (J. Saarela, M. Rehn, S. Vainio and T. Pihlajaniemi, unpublished). ELQ recognizes all three