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7 papers found.
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A randomized phase II study of S-1 plus oral leucovorin versus S-1 monotherapy in patients with gemcitabine-refractory advanced pancreatic cancer†

Background We evaluated the efficacy and toxicity of adding oral leucovorin (LV) to S-1 when compared with S-1 monotherapy in patients with gemcitabine-refractory pancreatic cancer (PC).

Invasion of Ureaplasma diversum in Hep-2 cells

Background Understanding mollicutes is challenging due to their variety and relationship with host cells. Invasion has explained issues related to their opportunistic role. Few studies have been done on the Ureaplasma diversum mollicute, which is detected in healthy or diseased bovine. The invasion in Hep-2 cells of four clinical isolates and two reference strains of their ...

Circulating ghrelin concentrations are lowered by intracerebroventricular insulin

M. Ueno J. B. C. Carvalheira R. L. G. S. Oliveira L. A. Velloso M. J. A. Saad 0 ) Department of Internal Medicine, State University of Campinas (UNICAMP) , Campinas, So Paulo 13081-970, Brazil Aims

IS1. hepato-biliary-pancreatic

Background Gemcitabine plus cisplatin combination (GC) therapy is the standard therapy for advanced biliary tract cancer (BTC). In previous trials, gemcitabine plus S-1 combination (GS) therapy and S-1 mono-therapy had shown considerable efficacy in patients with BTC. The aim of this trial is to evaluate the efficacy and safety of the two regimens and to determine which is more ...

Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway

M. Ueno . J. B. C. Carvalheira . R. C. Tambascia . R. M. N. Bezerra . M. E. Amaral . E. M. Carneiro . F. Folli . K. G. Franchini . M. J. A. Saad 0 0 F. Folli Department of Internal Medicine , HS

Vanillin (3-methoxy-4-hydroxybenzaldehyde) inhibits mutation induced by hydrogen peroxide, N-methyl-N-nitrosoguanidine and mitomycin C but not 137Cs γ-radiation at the CD59 locus in human–hamster hybrid AL cells

We have investigated the ability of the naturally occurring plant essence vanillin (3-methoxy-4-hydroxybenzaldehyde) to inhibit mutation at the CD59 locus on human chromosome 11 by hydrogen peroxide, N-methyl-N-nitrosoguanidine, mitomycin C and 137Cs γ-radiation in human–hamster hybrid AL cells. Previous studies using vanillin have suggested that it can inhibit chromosome ...