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Search: authors:"Malou van den Boogaard"

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OccuPeak: ChIP-Seq Peak Calling Based on Internal Background Modelling

ChIP-seq has become a major tool for the genome-wide identification of transcription factor binding or histone modification sites. Most peak-calling algorithms require input control datasets to model the occurrence of background reads to account for local sequencing and GC bias. However, the GC-content of reads in Input-seq datasets deviates significantly from that in ChIP-seq...

A novel fluorescent marker for molecular, structural and functional analysis of the cardiac conduction system

IntroductionThe function of the conduction system depends on structure, function and molecular composition of its components. Studying the relation between these aspects would greatly benefit from a mouse model in which the cells of the conduction system can be easily recognized in situ.MethodsWe generated a transgenic mouse model that expresses yellow fluorescent protein Venus...