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Search: authors:"Manabu Niimi"

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Comparative studies of three cholesteryl ester transfer proteins and their interactions with known inhibitors

Wang, Zhenming Liu, Ling Wang, Jun Xu, Jianglin Fan. Data curation: Ziyun Wang, Manabu Niimi, Qianzhi Ding, Ling Wang, Jifeng Zhang. Formal analysis: Ziyun Wang, Manabu Niimi, Qianzhi Ding, Zhenming ... Liu, Ling Wang, Jifeng Zhang. Funding acquisition: Jun Xu, Jianglin Fan. Investigation: Ziyun Wang, Manabu Niimi, Qianzhi Ding, Ling Wang, Jifeng Zhang. Methodology: Ziyun Wang, Manabu Niimi

Probucol inhibits the initiation of atherosclerosis in cholesterol-fed rabbits

Background Probucol and statin are often prescribed for treating atherosclerosis. These two drugs exhibit different mechanisms but it is unknown whether they have the same anti-atherogenic properties. In the current study, we examined whether these two drugs at optimal doses could inhibit the initiation of atherosclerosis in cholesterol-fed rabbits in the same way. Methods New...

Add-On Effect of Probucol in Atherosclerotic, Cholesterol-Fed Rabbits Treated with Atorvastatin

Objective Lowering the blood concentration of low-density lipoprotein (LDL) cholesterol is the primary strategy employed in treating atherosclerotic disorders; however, most commonly prescribed statins prevent cardiovascular events in just 30% to 40% of treated patients. Therefore, additional treatment is required for patients in whom statins have been ineffective. In this study...

Bisphenol A Exposure Enhances Atherosclerosis in WHHL Rabbits

Bisphenol A (BPA) is an environmental endocrine disrupter. Excess exposure to BPA may increase susceptibility to many metabolic disorders, but it is unclear whether BPA exposure has any adverse effects on the development of atherosclerosis. To determine whether there are such effects, we investigated the response of Watanabe heritable hyperlipidemic (WHHL) rabbits to 400-µg/kg...

Cilostazol Inhibits Accumulation of Triglyceride in Aorta and Platelet Aggregation in Cholesterol-Fed Rabbits

Cilostazol is clinically used for the treatment of ischemic symptoms in patients with chronic peripheral arterial obstruction and for the secondary prevention of brain infarction. Recently, it has been reported that cilostazol has preventive effects on atherogenesis and decreased serum triglyceride in rodent models. There are, however, few reports on the evaluation of cilostazol...