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Search: authors:"Mandy L. Roberts-Crowley"

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Modulation of CaV1.3b L-type calcium channels by M1 muscarinic receptors varies with CaVĪ² subunit expression

ObjectivesWe examined whether two G protein-coupled receptors (GPCRs), muscarinic M1 receptors (M1Rs) and dopaminergic D2 receptors (D2Rs), utilize endogenously released fatty acid to inhibit L-type Ca2+ channels, CaV1.3. HEK-293 cells, stably transfected with M1Rs, were used to transiently transfect D2Rs and CaV1.3b with different CaVĪ²-subunits, allowing for whole-cell current...

Characterization of ST14A Cells for Studying Modulation of Voltage-Gated Calcium Channels

In medium spiny neurons (MSNs) of the striatum, dopamine D2 receptors (D2Rs) specifically inhibit the Cav1.3 subtype of L-type Ca2+ channels (LTCs). MSNs are heterogeneous in their expression of dopamine receptors making the study of D2R pathways difficult in primary neurons. Here, we employed the ST14A cell line, derived from embryonic striatum and characterized to have...