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MicroRNA Biomarkers for Coronary Artery Disease?

King’s College London in partnership with King’s College Hospital. Compliance with Ethical Standards Conflict of Interest Dorothee Kaudewitz declares no conflict of interest. Anna Zampetaki and Manuel ... Mayr declare patent applications filed through King’s College London on miRNA biomarkers (issued and pending). Human and Animal Rights and Informed Consent This article does not contain any studies with

Proteomic and metabolomic changes driven by elevating myocardial creatine suggest novel metabolic feedback mechanisms

Mice over-expressing the creatine transporter have elevated myocardial creatine levels [Cr] and are protected against ischaemia/reperfusion injury via improved energy reserve. However, mice with very high [Cr] develop cardiac hypertrophy and dysfunction. To investigate these contrasting effects, we applied a non-biased hypothesis-generating approach to quantify global protein and...

T1 values by conservative septal postprocessing approach are superior in relating to the interstitial myocardial fibrosis: findings from patients with severe aortic stenosis

patients with severe aortic stenosis Nicholas Child May Lin Yap Darius Dabir Toby Rogers Gonca Suna banher sandhu David M Higgins Manuel Mayr Eike Nagel Valentina Puntmann - Background Accumulation of

From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on “New frontiers in cardiovascular research”

In this meeting report, particularly addressing the topic of protection of the cardiovascular system from ischemia/reperfusion injury, highlights are presented that relate to conditioning strategies of the heart with respect to molecular mechanisms and outcome in patients’ cohorts, the influence of co-morbidities and medications, as well as the contribution of innate immune...

Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside

Dicer can account for changes in the microRNA profile associated with other diseases remains to be determined. Finally, Manuel Mayr (UK) provided an overview from a systems biology perspective to help

Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas

Background HIF-1 deficiency has marked effects on tumour glycolysis and growth. We therefore investigated the consequences of HIF-1 deficiency in mice, using the well established Hepa-1 wild-type (WT) and HIF-1β-deficient (c4) model. These mechanisms could be clinically relevant, since HIF-1 is now a therapeutic target. Methods Hepa-1 WT and c4 tumours grown in vivo were analysed...