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Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort

England (MR/L01341X/ 1). Marc Chadeau-Hyam acknowledges support from Cancer Research UK, Population Research Committee Project Grant (‘Mechanomics’ Project #22184 to MC-H). This work was funded by the

Causal diagrams in systems epidemiology

Methods of diagrammatic modelling have been greatly developed in the past two decades. Outside the context of infectious diseases, systematic use of diagrams in epidemiology has been mainly confined to the analysis of a single link: that between a disease outcome and its proximal determinant(s). Transmitted causes ("causes of causes") tend not to be systematically analysed. The...

A life course approach to explore the biological embedding of socioeconomic position and social mobility through circulating inflammatory markers

Stringhini in:Nature Research journals • PubMed • Google ScholarSearch for Marc Chadeau-Hyam in:Nature Research journals • PubMed • Google Scholar Contributions Conception, hypothesis delineation and study ... financial interests. Corresponding author Correspondence to Marc Chadeau-Hyam. Supplementary information PDF files1.Supplementary Information Rights and permissions This work is licensed under a

The time machine: a simulation approach for stochastic trees

In this paper, we consider a simulation technique for stochastic trees. One of the most important areas in computational genetics is the calculation and subsequent maximization of the likelihood function associated with such models. This typically consists of using importance sampling and sequential Monte Carlo techniques. The approach proceeds by simulating the tree, backward in...

Dynamics of smoking-induced genome-wide methylation changes with time since smoking cessation

Several studies have recently identified strong epigenetic signals related to tobacco smoking. However, an aspect that did not receive much attention is the evolution of epigenetic changes with time since smoking cessation. We conducted a series of epigenome-wide association studies to capture the dynamics of smoking-induced epigenetic changes after smoking cessation, using...

Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis

Flower 1 Ed Curry 1 Nicholas Orr Katarzyna Tomczyk Michael E. Jones Alan Ashworth Anthony Swerdlow Marc Chadeau-Hyam 4 Eiliv Lund Montserrat Garcia-Closas Torkjel M. Sandanger James M. Flanagan 0 1 Paolo

Blood Erythrocyte Concentrations of Cadmium and Lead and the Risk of B-Cell Non-Hodgkin’s Lymphoma and Multiple Myeloma: A Nested Case-Control Study

BackgroundCadmium (Cd) and lead (Pb) are hypothesised to be risk factors for non-Hodgkin’s lymphoma (NHL), a group of haematological malignancies with a suspected environmental aetiology. Within the EnviroGenoMarkers study we utilised pre-diagnostic erythrocyte concentrations of Cd and Pb to determine whether exposure was associated with risk of B-cell NHL and multiple myeloma...

ESS++: a C++ objected-oriented algorithm for Bayesian stochastic search model exploration

Summary: ESS++ is a C++ implementation of a fully Bayesian variable selection approach for single and multiple response linear regression. ESS++ works well both when the number of observations is larger than the number of predictors and in the ‘large p, small n’ case. In the current version, ESS++ can handle several hundred observations, thousands of predictors and a few...

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects...

Fregene: Simulation of realistic sequence-level data in populations and ascertained samples

Background FREGENE simulates sequence-level data over large genomic regions in large populations. Because, unlike coalescent simulators, it works forwards through time, it allows complex scenarios of selection, demography, and recombination to be modelled simultaneously. Detailed tracking of sites under selection is implemented in FREGENE and provides the opportunity to test...

GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm

received funding from the Wellcome Trust Value-in-People award. Leonardo Bottolo and Sylvia Richardson acknowledge support from the Medical Research Council (grant G1002319). Marc Chadeau-Hyam acknowledges

Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking

Research journals • PubMed • Google ScholarSearch for Domenico Palli in:Nature Research journals • PubMed • Google ScholarSearch for Marc Chadeau-Hyam in:Nature Research journals • PubMed • Google

Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus

• Google ScholarSearch for Doug Speed in:Nature Research journals • PubMed • Google ScholarSearch for Prashant K. Srivastava in:Nature Research journals • PubMed • Google ScholarSearch for Marc Chadeau-Hyam