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16 papers found.
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Treatment with cinacalcet increases plasma sclerostin concentration in hemodialysis patients with secondary hyperparathyroidism

Background Sclerostin is a paracrine acting factor, which is expressed in the osteocytes and articular chondrocytes. Sclerostin decreases the osteoblast-related bone formation through the inhibition of the Wnt/β-catenin pathway. Osteocytes also express the Calcium sensing receptor which is a target for cinacalcet. The aim of this study was to assess the influence of six-month ...

Is inflammation a new risk factor of depression in haemodialysis patients?

ukasz Nowak 0 Marcin Adamczak 0 Andrzej Wiecek 0 0 . Nowak (&) M. Adamczak A. Wiecek Department of Nephrology, Endocrinology and Metabolic Disorders, Medical University of Silesia , Francuska 20-24

Indications for renal revascularization—the landscape after the ASTRAL study

Andrzej Wiecek 0 Jerzy Chudek 0 Marcin Adamczak 0 0 Department of Nephrology , Endocrinology and Metabolic Diseases , Medical University of Silesia , Katowice , Poland The Author 2010. Published

Plasma leptin and neuropeptide Y concentrations in patients with rheumatoid arthritis treated with infliximab, a TNF-α antagonist

TNF-α is one of the key proinflammatory cytokines in pathogenesis of rheumatoid arthritis (RA). TNF-α was also found to enhance synthesis of leptin. Leptin is mainly adipocyte-derived hormone controlling appetite and energy expenditure. It acts through inhibition of neuropeptide Y secretion. It is possible that TNF-α-induced leptin secretion contributes to body mass reduction in ...

High-Dose Enalapril Treatment Reverses Myocardial Fibrosis in Experimental Uremic Cardiomyopathy

Aims Patients with renal failure develop cardiovascular alterations which contribute to the higher rate of cardiac death. Blockade of the renin angiotensin system ameliorates the development of such changes. It is unclear, however, to what extent ACE-inhibitors can also reverse existing cardiovascular alterations. Therefore, we investigated the effect of high dose enalapril ...

Why is coronary heart disease of uraemic patients so frequent and so devastating?

challenge. Acknowledgements. Marcin Adamczak has been supported by a Marie Curie Fellowship of the European Community programme: Improving the Human Research Potential and the Socio-economic Knowledge Base

Renal histopathology

Introduction and Aims: Henoch-Schönlein purpura nephritis (HSPN) and immunoglobulin A nephropathy (IgAN) are considered to be a spectrum of one disease, and are indistinguishable immunohistopathologically. Recently, there has been emerging concern that crescents, the main histologic feature of HSPN, merely reflect active inflammation, thus may not useful in predicting long-term ...

Clinical studies in CKD 1-5

Introduction and Aims: Impaired kidney function is one of important factors participating in the pathogenesis of alterated endocrine function in elderly subjects. Adiponectin is an adipokine with antiatherosclerotic, cardioprotective and antidiabetic properties. The aim of present study was to estimate plasma adiponectin concentration and their relationship with estimated ...

Pathophysiology CKD 5D

Introduction and Aims: Previous studies have shown that the prevalence of depression is high in patients with chronic kidney disease (CKD). Depression is associated with increased cardiovascular mortality and the higher rate of suicides in these patients. However, up to now, there is no data concerning the prevalence of depression in haemodialyzed patients in Poland. The aim of the ...

DIALYSIS. PATHOPHYSIOLOGY AND CLINICAL STUDIES

Introduction and Aims: A high level of fibroblast growth factor 23 (FGF23) is a risk factor for mortality, and recent studies have linked FGF23 to parameters of volume homeostasis and an increased risk of heart failure. In hemodialysis (HD), a large ultrafiltration volume (UFV) is also associated with an increased mortality risk. We aimed to investigate whether circulating FGF23 ...

CKD-MBD II

Introduction and Aims: Vascular calcification is an important factor influencing cardiovascular complications and the vital prognosis in hemodialysis patients. However, a target level of PTH and a guide for medical practice to prevent vascular calcification are not clearly defined in the KDIGO's guidelines and are controversial. We investigated the development and progression of ...

Hypertension - human studies

Introduction and Aims:Stroke remains a major cause of disability and mortality in hemodialysis [HD] patients with studies deriving predominantly from US FMC LA n=6,890; RRI n=5,620]. Overall 2% of the cohort [n=575] experienced stroke events [Table 1; p-values shown if <0.1]. Older age, cerebrovascular comorbidity, higher mean pre-dialysis systolic blood pressure [SBP] and ...

Transplantation - basic

Introduction and Aims: Cyclosporine A (CsA) is often used immunosuppresive agent in the variety of clinical conditions (among other in autoimmune diseases and after organ transplantation). In utero exposure to immunosuppressive drugs may influence organogenesis of the offspring with a potentially increased risk of hypertension and CKD in adulthood. The aim of this study in rats was ...