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Search: authors:"Marcus R. Makowski"

23 papers found.
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Treatment effect of mTOR-inhibition on tissue composition of renal angiomyolipomas in tuberous sclerosis complex (TSC)

: Susanne Brakemeier, Bianca Zukunft, Gerd Diederichs, Klemens Budde, Marcus R. Makowski. Data curation: Lars Vogt, Bianca Zukunft, Gerd Diederichs, Marcus R. Makowski. Formal analysis: Susanne Brakemeier ... . Investigation: Lisa Adams, Gerd Diederichs. Methodology: Marcus R. Makowski. Supervision: Bernd Hamm, Klemens Budde. Validation: Susanne Brakemeier, Marcus R. Makowski. Writing ± original draft: Susanne

Potential of asphericity as a novel diagnostic parameter in the evaluation of patients with 68Ga-PSMA-HBED-CC PET-positive prostate cancer lesions

Background The aim of this study was to evaluate the diagnostic value of the asphericity (ASP) as a novel quantitative parameter, reflecting the spatial heterogeneity of tracer uptake, in the staging process of patients with 68Ga-PSMA-HBED-CC positron emission tomography (PET)-positive prostate cancer (PC). In this study, 37 patients (median age 72 years, range 52–82 years) with...

Contrast-enhanced magnetic resonance imaging for the detection of ruptured coronary plaques in patients with acute myocardial infarction

, Marcus R. Makowski. Writing ± review & editing: Christian H. P. Jansen, Divaka Perera, Andrea J. Wiethoff, Alkys tis Phinikaridou, Reza M. Razavi, Aldo Rinaldi, Mike S. Marber, Gerald F. Greil, Eike ... Nagel, David Maintz, Simon Redwood, Rene M. Botnar, Marcus R. Makowski. 14 / 17 2. Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role

In vivo MR-angiography for the assessment of aortic aneurysms in an experimental mouse model on a clinical MRI scanner: Comparison with high-frequency ultrasound and histology

Background MR-angiography currently represents one of the clinical reference-standards for the assessment of aortic-dimensions. For experimental research in mice, dedicated preclinical high-field MRI scanners are used in most studies. This type of MRI scanner is not available in most institutions. The aim of this study was to evaluate the potential of MR-angiography performed on...

Diagnostic accuracy of susceptibility-weighted magnetic resonance imaging for the evaluation of pineal gland calcification

Objectives To determine the diagnostic performance of susceptibility-weighted magnetic resonance imaging (SWMR) for the detection of pineal gland calcifications (PGC) compared to conventional magnetic resonance imaging (MRI) sequences, using computed tomography (CT) as a reference standard. Methods 384 patients who received a 1.5 Tesla MRI scan including SWMR sequences and a CT...

Influence of acquired obesity on coronary vessel wall late gadolinium enhancement in discordant monozygote twins

Objectives The aim of this study was to investigate the impact of BMI on late gadolinium enhancement (LGE) of the coronary artery wall in identical monozygous twins discordant for BMI. Coronary LGE represents a useful parameter for the detection and quantification of atherosclerotic coronary vessel wall disease. Methods Thirteen monozygote female twin pairs (n = 26) with...

Cardiovascular magnetic resonance myocardial feature tracking detects quantitative wall motion during dobutamine stress

Background Dobutamine stress cardiovascular magnetic resonance (DS-CMR) is an established tool to assess hibernating myocardium and ischemia. Analysis is typically based on visual assessment with considerable operator dependency. CMR myocardial feature tracking (CMR-FT) is a recently introduced technique for tissue voxel motion tracking on standard steady-state free precession...

Single breath-hold assessment of cardiac function using an accelerated 3D single breath-hold acquisition technique - comparison of an intravascular and extravascular contrast agent

BackgroundCardiovascular magnetic resonance (CMR) is the current gold standard for the assessment of left ventricular (LV) function. Repeated breath-holds are needed for standard multi-slice 2D cine steady-state free precession sequences (M2D-SSFP). Accelerated single breath-hold techniques suffer from low contrast between blood pool and myocardium. In this study an intravascular...