Affiliations Yale-NUS College, 16 College Avenue West, Singapore, 138527, Singapore Andreas Heinecke & Maria De Iorio Department of Statistical Science, University College London, Gower Street, London, WC1E ... 6BT, UK Marta Tallarita & Maria De Iorio AuthorsAndreas Heinecke View author publications You can also search for this author in PubMed Google Scholar Marta Tallarita View author publications
provided by Horizon 2020 Framework Programme (Grant No. EC654241) and China Sponsorship Council. Compliance with ethical standards Conflict of interest Lifeng Ye, Maria De Iorio and Timothy M. D. Ebbels
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Introduction and hypothesis Urinary dipsticks and culture analyses of a mid-stream urine specimen (MSU) at 105 cfu ml−1 of a known urinary pathogen are considered the gold standard investigations for diagnosing urinary tract infection (UTI). However, the reliability of these tests has been much criticised and they may mislead. It is now widely accepted that pyuria (≥1 WBC μl−1...
). Compliance with Ethical Standards Conflict of Interest Gregory D. Tredwell, Jacob G. Bundy, Maria De Iorio and Timothy M. D. Ebbels declare that they have no conflict of interest. Ethical approval All
PurposeLower urinary tract symptoms (LUTS) may be associated with chronic urinary tract infection (UTI) undetected by routine diagnostic tests. Antimicrobial therapy might confer benefit for these patients.Materials and methodsOver 10 years, we treated patients with chronic LUTS. Pyuria was adopted as the principal biomarker of infection. Urinary leucocyte counts were recorded...
Background Technological developments have increased the feasibility of large scale genetic association studies. Densely typed genetic markers are obtained using SNP arrays, next-generation sequencing technologies and imputation. However, SNPs typed using these methods can be highly correlated due to linkage disequilibrium among them, and standard multiple regression techniques...
. Author information AffiliationsDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UKErika Cule, Paolo Vineis & Maria De Iorio AuthorsSearch for Erika ... Cule in:PubMed • Google Scholar Search for Paolo Vineis in:PubMed • Google Scholar Search for Maria De Iorio in:PubMed • Google Scholar Corresponding author Correspondence to Erika Cule
In this paper, we consider a simulation technique for stochastic trees. One of the most important areas in computational genetics is the calculation and subsequent maximization of the likelihood function associated with such models. This typically consists of using importance sampling and sequential Monte Carlo techniques. The approach proceeds by simulating the tree, backward in...
Motivation: Nuclear Magnetic Resonance (NMR) spectra are widely used in metabolomics to obtain metabolite profiles in complex biological mixtures. Common methods used to assign and estimate concentrations of metabolites involve either an expert manual peak fitting or extra pre-processing steps, such as peak alignment and binning. Peak fitting is very time consuming and is subject...
Background Probing the complex fusion of genetic and environmental interactions, metabolic profiling (or metabolomics/metabonomics), the study of small molecules involved in metabolic reactions, is a rapidly expanding 'omics' field. A major technique for capturing metabolite data is 1H-NMR spectroscopy and this yields highly complex profiles that require sophisticated statistical...
London, UKTimothy MD Ebbels AuthorsSearch for Harriet J Muncey in:PubMed • Google Scholar Search for Rebecca Jones in:PubMed • Google Scholar Search for Maria De Iorio in:PubMed • Google Scholar Search
Background Adenosine-5′-triphosphate (ATP) is a neurotransmitter and inflammatory cytokine implicated in the pathophysiology of lower urinary tract disease. ATP additionally reflects microbial biomass thus has potential as a surrogate marker of urinary tract infection (UTI). The optimum clinical sampling method for ATP urinalysis has not been established. We tested the potential...
Adenosine-5′-triphosphate (ATP) is a neurotransmitter and inflammatory cytokine implicated in the pathophysiology of lower urinary tract disease. ATP additionally reflects microbial biomass thus has potential as a surrogate marker of urinary tract infection (UTI). The optimum clinical sampling method for ATP urinalysis has not been established. We tested the potential of urinary...
Beatriz Valcrcel Timothy M. D. Ebbels Antti J. Kangas Pasi Soininen Paul Elliot Mika Ala-Korpela Marjo-Riitta Jrvelin Maria de Iorio connections between genetic variants and complex traits: an ... . http://dx.doi.org/10.1098/rsif.2013.0908 Received: 6 October 2013 Accepted: 5 February 2014 Subject Areas: systems biology Author for correspondence: Maria de Iorio e-mail: Electronic supplementary
Multilocus analysis of single nucleotide polymorphism haplotypes is a promising approach to dissecting the genetic basis of complex diseases. We propose a coalescent-based model for association mapping that potentially increases the power to detect disease-susceptibility variants in genetic association studies. The approach uses Bayesian partition modelling to cluster haplotypes...
Oxford , Oxford , UK and Department of Epidemiology and Public Health, Imperial College , London, UK MARIA DE IORIO c The Author 2006. Published by Oxford University Press. All rights reserved. For
Testing one SNP at a time does not fully realise the potential of genome-wide association studies to identify multiple causal variants, which is a plausible scenario for many complex diseases. We show that simultaneous analysis of the entire set of SNPs from a genome-wide study to identify the subset that best predicts disease outcome is now feasible, thanks to developments in...
Motivation: Large-scale genetic association studies are carried out with the hope of discovering single nucleotide polymorphisms involved in the etiology of complex diseases. There are several existing methods in the literature for performing this kind of analysis for case-control studies, but less work has been done for prospective cohort studies. We present a Bayesian method...