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Search: authors:"Maria Ninova"

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Pervasive microRNA Duplication in Chelicerates: Insights from the Embryonic microRNA Repertoire of the Spider Parasteatoda tepidariorum

MicroRNAs are small (∼22 nt) noncoding RNAs that repress translation and therefore regulate the production of proteins from specific target mRNAs. microRNAs have been found to function in diverse aspects of gene regulation within animal development and many other processes. Among invertebrates, both conserved and novel, lineage specific, microRNAs have been extensively studied...

Conserved Temporal Patterns of MicroRNA Expression in Drosophila Support a Developmental Hourglass Model

Maria Ninova 0 Matthew Ronshaugen 0 Sam Griffiths-Jones 0 0 Faculty of Life Sciences, University of Manchester , Manchester, United Kingdom The spatiotemporal control of gene expression is crucial

Clusters of microRNAs emerge by new hairpins in existing transcripts

Genetic linkage may result in the expression of multiple products from a polycistronic transcript, under the control of a single promoter. In animals, protein-coding polycistronic transcripts are rare. However, microRNAs are frequently clustered in the genomes of animals, and these clusters are often transcribed as a single unit. The evolution of microRNA clusters has been the...

Target Repression Induced by Endogenous microRNAs: Large Differences, Small Effects

Ninova 0 Sam Griffiths-Jones 0 Matthew Ronshaugen 0 A. Aziz Aboobaker, University of Oxford, United Kingdom 0 Faculty of Life Sciences, The University of Manchester , Manchester , United Kingdom

Conservation and Losses of Non-Coding RNAs in Avian Genomes

Here we present the results of a large-scale bioinformatics annotation of non-coding RNA loci in 48 avian genomes. Our approach uses probabilistic models of hand-curated families from the Rfam database to infer conserved RNA families within each avian genome. We supplement these annotations with predictions from the tRNA annotation tool, tRNAscan-SE and microRNAs from miRBase. We...