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Serum adiponectin levels are associated with worse cognitive function in postmenopausal women

participants. However, the findings need to be confirmed in larger and longitudinal study. Author Contributions seppe Paolisso, Maria Rosaria Rizzo. Data curation: Maria Rosaria Rizzo. Conceptualization ... : Pasquale De Franciscis, Michelangela Barbieri, Nicola Colacurci, Giu Formal analysis: Michelangela Barbieri, Raffaele Marfella, Maria Rosaria Rizzo. Methodology: Pasquale De Franciscis, Michelangela

Cardiac Resynchronization Therapy Outcomes in Type 2 Diabetic Patients: Role of MicroRNA Changes

Heart failure (HF) and type 2 diabetes mellitus (T2DM) are two growing and related diseases in general population and particularly in elderly people. In selected patients affected by HF and severe dysfunction of left ventricle ejection fraction (LVEF), with left bundle brunch block, the cardiac resynchronization therapy with a defibrillator (CRT) is the treatment of choice to...

Awaking Blood Pressure Surge and Progression to Microalbuminuria in Type 2 Normotensive Diabetic Patients

normotensive adult patients with type 2 diabetes. Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper. Authors’ Contribution Maria Rosaria ... Rizzo researched data. Raffaele Marfella wrote the paper and researched data. Giuseppe Paolisso, Pasquale Paolisso, Angela Abbatecola, Nicola Angelico, and Celestino Sardu reviewed, edited, and wrote the

Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes: Role of dipeptidyl peptidase-IV inhibition

MARIA ROSARIA RIZZO PHD MICHELANGELA BARBIERI PHD RAFFAELE MARFELLA PHD GIUSEPPE PAOLISSO PHD OBJECTIVEdEvaluate the effects of two dipeptidyl peptidase-IV (DPP-4) inhibitors, sitagliptin and

Association of Genetic Variation in Adaptor Protein APPL1/APPL2 Loci with Non-Alcoholic Fatty Liver Disease

The importance of genetics and epigenetic changes in the pathogenesis of non alcoholic fatty liver disease (NAFLD) has been increasingly recognized. Adiponectin has a central role in regulating glucose and lipid metabolism and controlling inflammation in insulin-sensitive tissues and low adiponectin levels have been linked to NAFLD. APPL1 and APPL2 are adaptor proteins that...

Comorbidities and Crash Involvement among Younger and Older Drivers

Previous studies identified comorbidities as predictors of older driver performance and driving pattern, while the direct impact of comorbidities on road crash risk in elderly drivers is still unknown. The present study is a cross-sectional aimed at investigating the association between levels of comorbidity and crash involvement in adult and elderly drivers. 327 drivers were...

Mediterranean Diet, Telomere Maintenance and Health Status among Elderly

Leukocyte telomere length (LTL) and rate of telomere shortening are known biomarkers of aging while, numerous studies showed that Mediterranean diet (MD) may boost longevity. We studied association between telomere length, telomerase activity and different adherence to MD and its effects on healthy status. The study was conducted in 217 elderly subjects stratified according...

Serum Oxidative Stress Markers and Lipidomic Profile to Detect NASH Patients Responsive to an Antioxidant Treatment: A Pilot Study

Ferranti,2 Carmela De Simone,2 Maria Rosaria Rizzo,3 Concetta Tuccillo,4 Michele Caraglia,1 Carmelina Loguercio,4 and Alessandro Federico4 1Department of Biochemistry, Biophysics and General Pathology

Relationships Between Daily Acute Glucose Fluctuations and Cognitive Performance Among Aged Type 2 Diabetic Patients

MARIA ROSARIA RIZZO PHD RAFFAELE MARFELLA PHD MICHELANGELA BARBIERI PHD VIRGINIA BOCCARDI FRANCESCO VESTINI BIAGIO LETTIERI SILVESTRO CANONICO GIUSEPPE PAOLISSO PHD OBJECTIVE - The mean amplitude of

Dipeptidyl Peptidase 4 Inhibition May Facilitate Healing of Chronic Foot Ulcers in Patients with Type 2 Diabetes

The pathophysiology of chronic diabetic ulcers is complex and still incompletely understood, both micro- and macroangiopathy strongly contribute to the development and delayed healing of diabetic wounds, through an impaired tissue feeding and response to ischemia. With adequate treatment, some ulcers may last only weeks; however, many ulcers are difficult to treat and may last...

Bariatric Surgery Reduces Oxidative Stress by Blunting 24-h Acute Glucose Fluctuations in Type 2 Diabetic Obese Patients

RAFFAELE MARFELLA PHD MICHELANGELA BARBIERI PHD ROBERTO RUGGIERO MARIA ROSARIA RIZZO PHD RODOLFO GRELLA PHD ANNA LICIA MOZZILLO LUDOVICO DOCIMO GIUSEPPE PAOLISSO PHD OBJECTIVE We evaluated the

Effects of PPARs Agonists on Cardiac Metabolism in Littermate and Cardiomyocyte-Specific PPAR-γ –Knockout (CM-PGKO) Mice

Understanding the molecular regulatory mechanisms controlling for myocardial lipid metabolism is of critical importance for the development of new therapeutic strategies for heart diseases. The role of PPARγ and thiazolidinediones in regulation of myocardial lipid metabolism is controversial. The aim of our study was to assess the role of PPARγ on myocardial lipid metabolism and...