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Alterations in the programming of energy metabolism in adolescents with background exposure to dioxins, dl-PCBs and PBDEs

, and the OBELIX consortium for their advice and critique. Author Contributions Conceptualization: Marike M. Leijs, Janna G. Koppe, Thomas Vulsma, Kees Olie, Wim M. C. van Aalderen, Pim de Voogt, Gavin ... W. ten Tusscher. Data curation: Marike M. Leijs, Janna G. Koppe, Gavin W. ten Tusscher. Formal analysis: Marike M. Leijs, Gavin W. ten Tusscher. Funding acquisition: Janna G. Koppe. Investigation

Thyroid hormone metabolism and environmental chemical exposure

Background Polychlorinated dioxins and –furans (PCDD/Fs) and polychlorinated-biphenyls (PCBs) are environmental toxicants that have been proven to influence thyroid metabolism both in animal studies and in human beings. In recent years polybrominated diphenyl ethers (PBDEs) also have been found to have a negative influence on thyroid hormone metabolism. The lower brominated flame ...