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8 papers found.
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Mechanical fibrinogen-depletion supports heparin-free mesenchymal stem cell propagation in human platelet lysate

Background Pooled human platelet lysate (pHPL) is an efficient alternative to xenogenic supplements for ex vivo expansion of mesenchymal stem cells (MSCs) in clinical studies. Currently, porcine heparin is used in pHPL-supplemented medium to prevent clotting due to plasmatic coagulation factors. We therefore searched for an efficient and reproducible medium preparation method...

Regulation of the actin cytoskeleton in Helicobacter pylori-induced migration and invasive growth of gastric epithelial cells

Dynamic rearrangement of the actin cytoskeleton is a significant hallmark of Helicobacter pylori (H. pylori) infected gastric epithelial cells leading to cell migration and invasive growth. Considering the cellular mechanisms, the type IV secretion system (T4SS) and the effector protein cytotoxin-associated gene A (CagA) of H. pylori are well-studied initiators of distinct signal...

Actin cytoskeleton remodelling via local inhibition of contractility at discrete microdomains

Gerald Burgstaller 0 Mario Gimona ( 0 0 Institute of Molecular Biology, Department of Cell Biology, Austrian Academy of Sciences , Billrothstrasse 11, 5020 Salzburg

UNC-87, a calponin-related protein in C. elegans, antagonizes ADF/cofilin-mediated actin filament dynamics

Sawako Yamashiro 1 Mario Gimona 0 Shoichiro Ono ) 1 0 Unit of Actin Cytoskeleton Regulation, Consorzio Mario Negri Sud, Department of Cell Biology and Oncology , Via Nazionale 8a, 66030 Santa Maria

Candida albicans AGE3, the Ortholog of the S. cerevisiae ARF-GAP-Encoding Gene GCS1, Is Required for Hyphal Growth and Drug Resistance

Background Hyphal growth and multidrug resistance of C. albicans are important features for virulence and antifungal therapy of this pathogenic fungus. Methodology/Principal Findings Here we show by phenotypic complementation analysis that the C. albicans gene AGE3 is the functional ortholog of the yeast ARF-GAP-encoding gene GCS1. The finding that the gene is required for...

Dystroglycan, Tks5 and Src Mediated Assembly of Podosomes in Myoblasts

from the Academy of Finland, the Sigrid Juselius Foundation, and Helsinki University Hospital EVO funds to Kalle Saksela and a Marie Curie Excellence grant 002573 from the European Union to Mario Gimona