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Search: authors:"Mario Petretta MD"

10 papers found.
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The “gray zone” for the heart to mediastinum MIBG uptake ratio

Increased myocardial sympathetic activity is an important feature of heart failure (HF) and is associated with progressive myocardial remodeling, worsening in left ventricular (LV) function, and poor outcome.1-3 The AdreView Myocardial Imaging for Risk Evaluation in Heart Failure (ADMIRE-HF) study prospectively evaluated the value of quantitation of sympathetic innervation of the ...

Pitfalls in statistical methods

To the Editor:We red with great interest the study of Koh et al1 and the related editorial.2 Gibbons and Hodge2 outlined the importance to avoid surrogate end-points as outcomes in prognostic study and stressed the importance of the number of events (and not merely of the sample size) as critical for the power of prognostic studies. However, as regards the criticism to the 95% ...

Warranty period of normal stress myocardial perfusion imaging in diabetic patients: A propensity score analysis

Background We evaluated the relationship between diabetes and temporal characteristics of cardiac risk at long-term follow-up in a propensity score-matched cohort of diabetic and non-diabetic patients with normal stress myocardial perfusion single-photon emission computed tomography (MPS). Methods and Results We studied 828 consecutive patients with suspected or known coronary ...

Detection of silent myocardial ischemia: Is it clinically relevant?

Silent myocardial ischemia is defined as objective documentation of myocardial ischemia in the absence of angina or anginal equivalents.1 The first description of silent ischemia date to the 1970s, but despite intensive investigation, its pathophysiology, detection, prevalence, and clinical significance are still debated. The need and the benefit of treating silent ischemia, ...