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The serotonergic system in Parkinson’s patients with dyskinesia: evidence from imaging studies

Marios Politis 0 0 Neurodegeneration Imaging Group, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London , 125 Coldharbour Lane ... , Camberwell, London SE5 9NU , UK 1 Marios Politis The purpose of review is to review the current status of positron emission tomography (PET) molecular imaging of serotonergic system in Parkinson's patients

A systematic review of lessons learned from PET molecular imaging research in atypical parkinsonism

, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London , London , UK 1 Marios Politis Purpose To systematically review the previous studies and current status of positron ... aggregate formation. Acknowledgments Marios Politis research is supported by Parkinson’s UK, Lily and Edmond J. Safra Foundation, Michael J Fox Foundation (MJFF) for Parkinson’s research, and KCL’s NIHR

Current status of PET imaging in Huntington’s disease

1 Marios Politis Purpose To review the developments of recent decades and the current status of PET molecular imaging in Huntington's disease (HD). Methods A systematic review of PET studies in HD

Cholinergic imaging in dementia spectrum disorders

of Basic & Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London , London , UK 1 Marios Politis The multifaceted nature of the pathology of dementia

Optimizing functional imaging protocols for assessing the outcome of fetal cell transplantation in Parkinson's disease

Clinical trials aiming to assess the safety and efficacy of fetal cell transplantation in Parkinson's disease rely on the hypothesis that the grafted tissue will survive and grow, restore striatal dopaminergic neurotransmission, improve the connectivity between striatum, thalamus and cortex and, thereby, produce long-lasting clinical improvement while avoiding the development of ...

Dyskinesias after neural transplantation in Parkinson's disease: what do we know and what is next?

Since the 1980 s, when cell transplantation into the brain as a cure for Parkinson's disease hit the headlines, several patients with Parkinson's disease have received transplantation of cells from aborted fetuses with the aim of replacing the dopamine cells destroyed by the disease. The results in human studies were unpredictable and raised controversy. Some patients showed ...

Clinical application of stem cell therapy in Parkinson's disease

Cell replacement therapies in Parkinson's disease (PD) aim to provide long-lasting relief of patients' symptoms. Previous clinical trials using transplantation of human fetal ventral mesencephalic (hfVM) tissue in the striata of PD patients have provided proof-of-principle that such grafts can restore striatal dopaminergic (DA-ergic) function. The transplants survive, reinnervate ...

Acute HCV/HIV Coinfection Is Associated with Cognitive Dysfunction and Cerebral Metabolite Disturbance, but Not Increased Microglial Cell Activation

Background Microglial cell activation and cerebral function impairment are described in both chronic hepatitis C viral (HCV) and Human-Immune-Deficiency viral (HIV) infections. The aim of this study was to investigate the effect of acute HCV infection upon cerebral function and microglial cell activation in HIV-infected individuals. Methods A case-control study was conducted. ...