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7 papers found.
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Diagnosis of bronchiectasis and airway wall thickening in children with cystic fibrosis: Objective airway-artery quantification

Objectives To quantify airway and artery (AA)-dimensions in cystic fibrosis (CF) and control patients for objective CT diagnosis of bronchiectasis and airway wall thickness (AWT). Methods Spirometer-guided inspiratory and expiratory CTs of 11 CF and 12 control patients were collected retrospectively. Airway pathways were annotated semi-automatically to reconstruct three...

The development of bronchiectasis on chest computed tomography in children with cystic fibrosis: can pre-stages be identified?

financially supporting Marleen de Bruijne and Vertex for financially supporting Adria Perex Rovira. Harm. A.W.M. Tiddens is heading the ErasmusMC image analysis core laboratory LungAnalysis. Furthermore, the

Quantification of Diaphragm Mechanics in Pompe Disease Using Dynamic 3D MRI

Background Diaphragm weakness is the main reason for respiratory dysfunction in patients with Pompe disease, a progressive metabolic myopathy affecting respiratory and limb-girdle muscles. Since respiratory failure is the major cause of death among adult patients, early identification of respiratory muscle involvement is necessary to initiate treatment in time and possibly...

Lung MRI and impairment of diaphragmatic function in Pompe disease

Background Pompe disease is a progressive metabolic myopathy. Involvement of respiratory muscles leads to progressive pulmonary dysfunction, particularly in supine position. Diaphragmatic weakness is considered to be the most important component. Standard spirometry is to some extent indicative but provides too little insight into diaphragmatic dynamics. We used lung MRI to study...

Atherosclerotic Plaque Component Segmentation in Combined Carotid MRI and CTA Data Incorporating Class Label Uncertainty

Molecular Medicine (, project PARISk (grant 01C-202), and supported by the Dutch Heart Foundation. Wiro Niessen, Stefan Klein and Marleen de Bruijne were financially supported by the Netherlands

Distribution, size, shape, growth potential and extent of abdominal aortic calcified deposits predict mortality in postmenopausal women

Background Aortic calcification is a major risk factor for death from cardiovascular disease. We investigated the relationship between mortality and the composite markers of number, size, morphology and distribution of calcified plaques in the lumbar aorta. Methods 308 postmenopausal women aged 48-76 were followed for 8.3 ± 0.3 years, with deaths related to cardiovascular disease...

A Genome-Wide Association Study Identifies Five Loci Influencing Facial Morphology in Europeans

Bruijne M. Arfan Ikram Aad van der Lugt Fernando Rivadeneira Andre G. Uitterlinden Albert Hofman Wiro J. Niessen Georg Homuth Greig de Zubicaray Katie L. McMahon Paul M. Thompson Amro Daboul Ralf Puls