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The plastoquinone pool of Nannochloropsis oceanica is not completely reduced during bright light pulses

The lipid-producing model alga Nannochloropsis oceanica has a distinct photosynthetic machinery. This organism possesses chlorophyll a as its only chlorophyll species, and has a high ratio of PSI to PSII. This high ratio of PSI to PSII may affect the redox state of the plastoquinone pool during exposure to light, and consequently may play a role in activating photoprotection...

Cost-Effectiveness of Pharmacogenomic and Pharmacogenetic Test-Guided Personalized Therapies: A Systematic Review of the Approved Active Substances for Personalized Medicine in Germany

published. Marika Plo¨thner, the corresponding author, is responsible for the study design and the initial draft. Dana Ribbentrop, Jan-Phillipp Hartman, and Martin Frank contributed to the manuscript through

Comparison of different approaches applied in Analytic Hierarchy Process – an example of information needs of patients with rare diseases

Background The Analytic Hierarchy Process (AHP) is increasingly used to measure patient priorities. Studies have shown that there are several different approaches to data acquisition and data aggregation. The aim of this study was to measure the information needs of patients having a rare disease and to analyze the effects of these different AHP approaches. The ranking of...

Asynchronous Changes in Vegetation, Runoff and Erosion in the Nile River Watershed during the Holocene

Martin Frank 0 Stefan Schouten 1 0 GEOMAR Helmholtz Centre for Ocean Research Kiel , Kiel, Germany, 1 Department of Marine Organic Biogeochemistry, NIOZ-Royal Netherlands Institute for Sea Research, 't

Rare is frequent and frequent is costly: rare diseases as a challenge for health care systems

J.-Matthias Graf von der Schulenburg 0 Martin Frank 0 0 J.-M. Graf von der Schulenburg (&) M. Frank Center for Health Economics Research Hannover, Leibniz University Hannover , Konigsworther Platz 1

Understanding the Specificity of Human Galectin-8C Domain Interactions with Its Glycan Ligands Based on Molecular Dynamics Simulations

preparation of the manuscript. Competing Interests: Dr. Martin Frank is employed by Biognos AB in Gothenburg, Sweden. He declares that he does not have any financial, non-financial, professional or personal

Bioinformatics and molecular modeling in glycobiology

The field of glycobiology is concerned with the study of the structure, properties, and biological functions of the family of biomolecules called carbohydrates. Bioinformatics for glycobiology is a particularly challenging field, because carbohydrates exhibit a high structural diversity and their chains are often branched. Significant improvements in experimental analytical...

A systematic review of the cost-effectiveness of targeted therapies for metastatic non-small cell lung cancer (NSCLC)

Background Non-small cell lung cancer (NSCLC) imposes a substantial burden on patients, health care systems and society due to increasing incidence and poor survival rates. In recent years, advances in the treatment of metastatic NSCLC have resulted from the introduction of targeted therapies. However, the application of these new agents increases treatment costs considerably...

A Sialic Acid Binding Site in a Human Picornavirus

The picornaviruses coxsackievirus A24 variant (CVA24v) and enterovirus 70 (EV70) cause continued outbreaks and pandemics of acute hemorrhagic conjunctivitis (AHC), a highly contagious eye disease against which neither vaccines nor antiviral drugs are currently available. Moreover, these viruses can cause symptoms in the cornea, upper respiratory tract, and neurological...

Genome sequencing: a systematic review of health economic evidence

Recently the sequencing of the human genome has become a major biological and clinical research field. However, the public health impact of this new technology with focus on the financial effect is not yet to be foreseen. To provide an overview of the current health economic evidence for genome sequencing, we conducted a thorough systematic review of the literature from 17...

Lewis histo-blood group α1,3/α1,4 fucose residues may both mediate binding to GII.4 noroviruses

Human noroviruses cause recurrent epidemics of gastroenteritis known to be dominated by the clinically important GII.4 genotype which recognizes human Secretor gene-dependent ABH histo-blood group antigens (HBGAs) as attachment factors. There is increasing evidence that GII.4 noroviruses have undergone evolutionary changes to recognize Lewis antigens and non-Secretor saliva. In...

Meteorology and oceanography of the Atlantic sector of the Southern Ocean—a review of German achievements from the last decade

In the early 1980s, Germany started a new era of modern Antarctic research. The Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research (AWI) was founded and important research platforms such as the German permanent station in Antarctica, today called Neumayer III, and the research icebreaker Polarstern were installed. The research primarily focused on the...

A Structure-Guided Mutation in the Major Capsid Protein Retargets BK Polyomavirus

. Competing Interests: The authors have declared that no competing interests exist. Dr. Martin Frank is employed by a company, Biognos AB in Gothenburg, Sweden. He declares that he does not have any financial

Symbol Nomenclature for Graphical Representations of Glycans

Carolyn R Bertozzi 2 11 Marilynn E Etzler 4 11 Martin Frank 0 17 29 Johannes FG Vliegenthart 0 16 29 Thomas Lütteke 0 20 21 29 Serge Perez 22 23 29 Evan Bolton 24 25 29 Pauline Rudd 26 27 James Paulson 32

GlycomeDB—a unified database for carbohydrate structures

GlycomeDB integrates the structural and taxonomic data of all major public carbohydrate databases, as well as carbohydrates contained in the Protein Data Bank, which renders the database currently the most comprehensive and unified resource for carbohydrate structures worldwide. GlycomeDB retains the links to the original databases and is updated at weekly intervals with the... A portal for querying across the digital world of carbohydrate sequences

Despite ongoing harmonization efforts, the major carbohydrate sequence databases following the first initiative in this field, CarbBank, are still isolated islands, with mechanisms for automatic structure exchange and comparison largely missing. This unfavorable situation has been overcome with a systematic data integration effort, resulting in the GlycomeDB, a meta-database for...

Dynamic aspects of antibody:oligosaccharide complexes characterized by molecular dynamics simulations and saturation transfer difference nuclear magnetic resonance

Carbohydrates are likely to maintain significant conformational flexibility in antibody (Ab):carbohydrate complexes. As demonstrated herein for the protective monoclonal Ab (mAb) F22-4 recognizing the Shigella flexneri 2a O-antigen (O-Ag) and numerous synthetic oligosaccharide fragments thereof, the combination of molecular dynamics simulations and nuclear magnetic resonance...

Carbohydrate Structure Suite (CSS): analysis of carbohydrate 3D structures derived from the PDB

Knowledge of the 3D structure of glycoproteins and protein–carbohydrate complexes is indispensable to fully understand the biological processes they are involved in. Carbohydrate Structure Suite is an attempt to automatically analyse carbohydrate structures contained in the PDB and make the results publicly available on the internet. Characteristic torsion angles, glycoprotein...

Bioinformatics for glycomics: Status, methods, requirements and perspectives

Claus-Wilhelm von der Lieth Andreas Bohne-Lang Klaus Karl Lohmann Martin Frank Date received (in revised form): th March Claus-Wilhelm von der Lieth is the leader of the molecular modelling group