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Search: authors:"Mary P E Slack"

12 papers found.
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The evidence for non-typeable Haemophilus influenzae as a causative agent of childhood pneumonia

Haemophilus influenzae type b (Hib) was a major cause of bacterial pneumonia in children prior to the introduction of Hib-conjugate vaccines. The widespread use of Hib-conjugate vaccines has resulted in a significant decline in the number of cases of invasive Hib disease, including bacteraemic pneumonia, in areas where the vaccine has been implemented. In many countries, non...

A review of the role of Haemophilus influenzae in community-acquired pneumonia

A review of the role of community-acquired pneumonia Mary P E Slack - Corresponding author: % " ! ? ! #MN$! 8# ! " Z¼ * $ Z¼ * $ % L + #M 8 %L+ # 8 %L+ $ 8 %L+ # # + #M X #Q X #Q ! # ! %8

Antibody Concentrations Against the Infecting Serotype in Vaccinated and Unvaccinated Children With Invasive Pneumococcal Disease in the United Kingdom, 2006–2013

Background. This study aimed to estimate, following invasive pneumococcal disease (IPD), the proportion of children with protective immunoglobulin G (IgG) concentrations against the infecting serotype compared with other vaccine serotypes, and to assess risk of recurrent IPD. Methods. Pneumococcal antibody concentrations were available for 413 children with vaccine-type IPD...

Invasive Pneumococcal Disease, Comorbidities, and Polysaccharide Vaccine Use in Children Aged 5–15 Years in England and Wales

Background. In the United Kingdom, the 23-valent pneumococcal polysaccharide vaccine (PPV23) is recommended in addition to routine pneumococcal conjugate vaccination for at-risk children aged ≥2 years. This study describes the epidemiology, serotype distribution, clinical characteristics, vaccination status, and reasons for nonvaccination in children aged 5–15 years with invasive...

Invasive Haemophilus influenzae Type b Disease in England and Wales: Who Is at Risk After 2 Decades of Routine Childhood Vaccination?

. Slack 0 Shamez N. Ladhani 1 0 Respiratory and Vaccine Preventable Bacterial Reference Unit, Public Health England , London , United Kingdom 1 Colindale Ave , London NW9 5EQ , UK Background. The

Impact of the 7-Valent Pneumococcal Conjugate Vaccine on Invasive Pneumococcal Disease in Infants Younger Than 90 Days in England and Wales

Background. Streptococcus pneumoniae is an uncommon but well-recognized cause of invasive bacterial disease in young infants. This study aimed to determine the impact of the 7-valent pneumococcal conjugate vaccine (PCV7) on invasive pneumococcal disease (IPD) in infants aged <90 days in England and Wales and describe their clinical characteristics following PCV7 introduction...

Using the Indirect Cohort Design to Estimate the Effectiveness of the Seven Valent Pneumococcal Conjugate Vaccine in England and Wales

Background The 7-valent pneumococcal conjugate vaccine (PCV-7) was introduced in the United Kingdom in 2006 with a 2,3 and 13month schedule, and has led to large decreases in invasive pneumococcal disease (IPD) caused by the vaccine serotypes in both vaccinated and unvaccinated cohorts. We estimated the effectiveness of PCV-7 against IPD. Methods and Findings We used enhanced...

Long-Term Immunological Follow-Up of Children with Haemophilus influenzae Serotype b Vaccine Failure in the United Kingdom

Background. It is not known how long children with Haemophilus influenzae serotype b (Hib) vaccine failure retain protective Hib antibody concentrations after infection. The objective of this study was to determine Hib antibody concentrations in children several years after infection and to identify risk factors for low antibody concentrations. Methods. The families of children...

Hospital Surveillance of Childhood Bacterial Meningitis in Senegal and the Introduction of Haemophilus influenzae Type b Conjugate Vaccine

Diallo, Iyane Sow, Mary P. E. Slack, Pape Coumba Faye, Mady Ba, Ndiouga Diallo, and Noel S. Weiss PATH, Dakar, Senegal ; PATH, Seattle, Washington ; Albert Royer Hospital , Dakar, Senegal ; LeDantec

Haemophilus influenzae Type b Vaccine Failure in Children Is Associated with Inadequate Production of High-Quality Antibody

Background. Despite the excellent immunogenicity of Haemophilus influenzae type b (Hib) conjugate vaccines, breakthrough cases of Hib disease still affect a small proportion of vaccinated children in the United Kingdom. We performed a retrospective study to compare the avidity of antibody directed against the Hib polysaccharide capsule (PRP) in children who experienced Hib...

Surveillance of Pneumococcal-Associated Disease among Hospitalized Children in Khanh Hoa Province, Vietnam

Background. To understand the epidemiology of childhood bacterial diseases, including invasive pneumococcal disease, prospective surveillance was conducted among hospitalized children in Nha Trang, Vietnam. Methods. From April 2005 through August 2006, pediatricians at the Khanh Hoa General Hospital used standardized screening criteria to identify children aged <5 years who had...