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16 papers found.
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The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication

, Kanazawa University Graduate School of Health Medicine, Kanazawa, JapanTakayoshi Shirasaki, Masao Honda, Ryougo Shimizu, Saki Nakasyo & Kazuhisa MuraiDepartment of General Medicine, Kanazawa University ... Search for Masao Honda in:Nature Research journals • PubMed • Google Scholar Search for Taro Yamashita in:Nature Research journals • PubMed • Google Scholar Search for Kouki Nio in:Nature Research

Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease

, Hajime Sunagozaka, Shuichi Kaneko. Data curation: Kazutoshi Yamada, Eishiro Mizukoshi. Formal analysis: Kazutoshi Yamada, Masao Honda. Funding acquisition: Eishiro Mizukoshi, Shuichi Kaneko ... . Investigation: Kazutoshi Yamada, Takuya Seike, Hajime Sunagozaka, Tatsuya Yamashita. Methodology: Eishiro Mizukoshi. Project administration: Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko. Resources: Rika Horii

Prognosis of type 1 autoimmune pancreatitis after corticosteroid therapy-induced remission in terms of relapse and diabetes mellitus

Kitamura, Kuniaki Arai, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Shuichi Kaneko. Resources: Koichiro Matsuda, Taku Sanada, Takeshi Urabe, Katsuhisa Inamura, Takashi

Potential efficacy of therapies targeting intrahepatic lesions after sorafenib treatment of patients with hepatocellular carcinoma

Background We investigated the contribution of subsequent therapy for advanced hepatocellular carcinoma refractory or intolerant to sorafenib. Further, we investigated the impact of sorafenib on overall survival using individual data. Methods We reviewed the medical records of patients with advanced hepatocellular carcinoma treated with sorafenib. Survival after sorafenib...

microRNA-122 Abundance in Hepatocellular Carcinoma and Non-Tumor Liver Tissue from Japanese Patients with Persistent HCV versus HBV Infection

Mechanisms of hepatic carcinogenesis in chronic hepatitis B and hepatitis C are incompletely defined but often assumed to be similar and related to immune-mediated inflammation. Despite this, several studies hint at differences in expression of miR-122, a liver-specific microRNA with tumor suppressor properties, in hepatocellular carcinoma (HCC) associated with hepatitis B virus...

Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma

Background The acyclic retinoid, peretinoin, has been shown to be effective for suppressing hepatocellular carcinoma (HCC) recurrence after definitive treatment in a small-scale randomized clinical trial. However, little has been documented about the mechanism by which peretinoin exerts its inhibitory effects against recurrent HCC in humans in vivo. Methods Twelve hepatitis C...

The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial

Aims/hypothesis The cholesterol absorption inhibitor ezetimibe has been shown to ameliorate non-alcoholic fatty liver disease (NAFLD) pathology in a single-armed clinical study and in experimental animal models. In this study, we investigated the efficacy of ezetimibe on NAFLD pathology in an open-label randomised controlled clinical trial. Methods We had planned to enrol 80...

CD14+ Monocytes Are Vulnerable and Functionally Impaired Under Endoplasmic Reticulum Stress in Patients With Type 2 Diabetes

Takuya Komura Yoshio Sakai Masao Honda Toshinari Takamura Kouji Matsushima Shuichi Kaneko OBJECTIVE-Although patients with diabetes suffer from increased infections and a higher incidence of cancer

Expression Profiling of Peripheral-Blood Mononuclear Cells from Patients with Chronic Hepatitis C Undergoing Interferon Therapy

BackgroundInterferon (IFN) is now the standard treatment for chronic hepatitis C (CH-C); however, treatment efficacy is unpredictable before IFN therapy is started MethodsWe investigated the gene-expression profiles of peripheral-blood mononuclear cells (PBMCs) from patients with CH-C showing different responses to IFN. Gene-expression profiles of PBMCs were analyzed in 21...

La Protein Required for Internal Ribosome Entry Site—Directed Translation Is a Potential Therapeutic Target for Hepatitis C Virus Replication

Background. Translation of the hepatitis C virus (HCV) is mediated by an internal ribosome entry site (IRES). Here, we analyzed the functional relevance of La protein for replication of HCV using an infectious HCV clone, JFH-1. Methods. A single-nucleotide mutation from A to U was introduced at the 338th nucleotide in the stem-loop domain IV structure of HCV IRES, which...

A randomized phase II trial of intra-arterial chemotherapy using SM-11355 (Miriplatin) for hepatocellular carcinoma

Background SM-11355 is a platinum complex developed to treat hepatocellular carcinoma (HCC) via administration into the hepatic artery as a sustained-release suspension in iodized oil. We conducted a multicenter phase II trial in patients with HCC to evaluate the efficacy and safety of SM-11355, using a Zinostatin stimalamer suspension in iodized oil as a reference. Methods...

Gene Systems Network Inferred from Expression Profiles in Hepatocellular Carcinogenesis by Graphical Gaussian Model

Hepatocellular carcinoma (HCC) in a liver with advanced-stage chronic hepatitis C (CHC) is induced by hepatitis C virus, which chronically infects about 170 million people worldwide. To elucidate the associations between gene groups in hepatocellular carcinogenesis, we analyzed the profiles of the genes characteristically expressed in the CHC and HCC cell stages by a statistical...

New Susceptibility and Resistance HLA-DP Alleles to HBV-Related Diseases Identified by a Trans-Ethnic Association Study in Asia

Tatsuya Ide Kazuhide Yamamoto Isao Sakaida Yoshikazu Murawaki Yoshito Itoh Akihiro Tamori Etsuro Orito Yoichi Hiasa Masao Honda Shuichi Kaneko Eiji Mita Kazuyuki Suzuki Keisuke Hino Eiji Tanaka Satoshi

Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C

Hematologic abnormalities during current therapy with pegylated interferon and ribavirin (PEG-IFN/RBV) for chronic hepatitis C (CHC) often necessitate dose reduction and premature withdrawal from therapy. The aim of this study was to identify host factors associated with IFN-induced thrombocytopenia by genome-wide association study (GWAS). In the GWAS stage using 900K single...

Genome-Wide Association Study Confirming Association of HLA-DP with Protection against Chronic Hepatitis B and Viral Clearance in Japanese and Korean

Matsuura Masaya Sugiyama Sang Hoon Ahn Jun Yong Park Shuhei Hige Jong-Hon Kang Kazuyuki Suzuki Masayuki Kurosaki Yasuhiro Asahina Satoshi Mochida Masaaki Watanabe Eiji Tanaka Masao Honda Shuichi Kaneko

No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations

Namiki Izumi Masao Honda Shuichi Kaneko Eiji Tanaka Kentaro Matsuura Yoshito Itoh Eiji Mita 7 Masaaki Korenaga 5 Keisuke Hino 5 Yoshikazu Murawaki 6 Yoichi Hiasa 3 Tatsuya Ide 4 Kiyoaki Ito Masaya Sugiyama