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Topics of nuclear medicine research in Europe

Radiology, Kawasaki Medical School , 577 Matsushima, Kurashiki 701-0192 , Japan 2 & Masayuki Inubushi 3 HIMEDIC Clinic WEST , 3-3-17 Minami Senba, Chuo-ku, Osaka 542-0081 , Japan 4 Department of Radiology

Introduction of nuclear medicine research in Japan

There were many interesting presentations of unique studies at the Annual Meeting of the Japanese Society of Nuclear Medicine, although there were fewer attendees from Europe than expected. These presentations included research on diseases that are more frequent in Japan and Asia than in Europe, synthesis of original radiopharmaceuticals, and development of imaging devices and...

Report of a nationwide survey on actual administered radioactivities of radiopharmaceuticals for diagnostic reference levels in Japan

Objective The optimization of medical exposure is one of the major issues regarding radiation protection in the world, and The International Committee of Radiological Protection and the International Atomic Energy Agency recommend establishing diagnostic reference levels (DRLs) as tools for dose optimization. Therefore, the development of DRLs based on the latest survey has been...

Detailed assessment of gene activation levels by multiple hypoxia-responsive elements under various hypoxic conditions

Objective HIF-1/HRE pathway is a promising target for the imaging and the treatment of intractable malignancy (HIF-1; hypoxia-inducible factor 1, HRE; hypoxia-responsive element). The purposes of our study are: (1) to assess the gene activation levels resulting from various numbers of HREs under various hypoxic conditions, (2) to evaluate the bidirectional activity of multiple...

Single-photon emission computed tomography of spontaneous liver metastasis from orthotopically implanted human colon cancer cell line stably expressing human sodium/iodide symporter reporter gene

Background We aimed to develop a mouse spontaneous liver metastasis model from an orthotopically implanted human colon cancer cell line stably expressing a human sodium/iodide symporter (NIS) reporter gene, which can be imaged with single-photon emission computed tomography (SPECT) using 99mTcO4 −. Methods A recombinant plasmid containing a constitutively driven NIS gene (pcDNA3...