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Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms

), for providing certain C. elegans RNAi clones. Author Contributions Conceptualization: Matteo Cornaglia. Data curation: Li Dong. Formal analysis: Li Dong. Funding acquisition: Martin A. M. Gijs ... . Investigation: Gopalan Krishnamani. Methodology: Li Dong. Supervision: Laurent Mouchiroud, Thomas Lehnert, Johan Auwerx, Martin A. M. Gijs. Validation: Li Dong, Matteo Cornaglia, Gopalan Krishnamani, Jingwei

Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models

Background While many biological studies can be performed on cell-based systems, the investigation of molecular pathways related to complex human dysfunctions – e.g. neurodegenerative diseases – often requires long-term studies in animal models. The nematode Caenorhabditis elegans represents one of the best model organisms for many of these tests and, therefore, versatile and...