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Search: authors:"Matthew P. Caley"

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Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces

cancer. Bone; Cell migration; Collagen; Fibroblast; Osteoblast; Prostate cancer - Matthew P. Caley, Helen King and Neel Shah have contributed equally to this work. Abbreviations AGE Advanced glycation

miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts

Uncontrolled cell proliferation and cytoskeletal remodeling are responsible for tumor development and ultimately metastasis. A number of studies have implicated microRNAs in the regulation of cancer cell invasion and migration. Here, we show that miR-23b regulates focal adhesion, cell spreading, cell-cell junctions and the formation of lamellipodia in breast cancer (BC...