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Search: authors:"Matthias König"

13 papers found.
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The pain threshold of high-threshold mechanosensitive receptors subsequent to maximal eccentric exercise is a potential marker in the prediction of DOMS associated impairment

Background Delayed-onset muscle soreness (DOMS) refers to dull pain and discomfort in people after participating in exercise, sport or recreational physical activities. The aim of this study was to detect underlying mechanical thresholds in an experimental model of DOMS. Methods Randomised study to detect mechanical pain thresholds in a randomised order following experimentally...

Exclusive weak radiative Higgs decays in the standard model and beyond

We perform a detailed study of the exclusive Higgs decays h → MZ and h → MW, where M is a pseudoscalar or vector meson, using the QCD factorization approach. We allow for the presence of new-physics effects in the form of modified Higgs couplings to gauge bosons and fermions, including the possibility of flavor-changing Higgs couplings. We show that the decays h → VZ exhibit a...

Exclusive radiative Higgs decays as probes of light-quark Yukawa couplings

We present a detailed analysis of the rare exclusive Higgs boson decays into a single vector meson and a photon and investigate the possibility of using these processes to probe the light-quark Yukawa couplings. We work with an effective Lagrangian with modified Higgs couplings to account for possible new-physics effects in a model-independent way. The h → Vγ decay rate is...

Exclusive radiative Z-boson decays to mesons with flavor-singlet components

We present a detailed study of the exclusive radiative decays Z → η (′) γ employing the QCD factorization approach. We derive a factorization formula for the decay amplitudes valid at leading power in an expansion in (ΛQCD /m Z )2, which includes convolutions of calculable hard-scattering kernels with the leading-twist quark and gluon light-cone distribution amplitudes of the...

Exclusive radiative decays of W and Z bosons in QCD factorization

We present a detailed theoretical analysis of very rare, exclusive hadronic decays of the electroweak gauge bosons V = W, Z from first principles of QCD. Our main focus is on the radiative decays V → Mγ, in which M is a pseudoscalar or vector meson. At leading order in an expansion in powers of ΛQCD /m V the decay amplitudes can be factorized into convolutions of calculable hard...

Dipole operator constraints on composite Higgs models

Flavour- and CP-violating electromagnetic or chromomagnetic dipole operators in the quark sector are generated in a large class of new physics models and are strongly constrained by measurements of the neutron electric dipole moment and observables sensitive to flavour-changing neutral currents, such as the \(B{\,\rightarrow \,} X_s\gamma \) branching ratio and \(\epsilon...

CySBML: a Cytoscape plugin for SBML

Summary: CySBML is a plugin designed to work with Systems Biology Markup Language (SBML) in Cytoscape having the following features: SBML import, support of the SBML layout and qualitative model packages, navigation in network layouts based on SBML structure, access to MIRIAM and SBO-based annotations and SBML validation. CySBML includes an importer for BioModels to load SBML...

Pathobiochemical signatures of cholestatic liver disease in bile duct ligated mice

Background Disrupted bile secretion leads to liver damage characterized by inflammation, fibrosis, eventually cirrhosis, and hepatocellular cancer. As obstructive cholestasis often progresses insidiously, markers for the diagnosis and staging of the disease are urgently needed. To this end, we compiled a comprehensive data set of serum markers, histological parameters and...

Quantifying the Contribution of the Liver to Glucose Homeostasis: A Detailed Kinetic Model of Human Hepatic Glucose Metabolism

Despite the crucial role of the liver in glucose homeostasis, a detailed mathematical model of human hepatic glucose metabolism is lacking so far. Here we present a detailed kinetic model of glycolysis, gluconeogenesis and glycogen metabolism in human hepatocytes integrated with the hormonal control of these pathways by insulin, glucagon and epinephrine. Model simulations are in...

Use of sodium thiosulphate in a multi-interventional setting for the treatment of calciphylaxis in dialysis patients

Background Calciphylaxis is a life-threatening complication in patients with end-stage renal disease (ESRD). No established therapy exists so far. The aim of the present study was to determine the therapeutic response to a multi-interventional treatment regimen with consistent use of sodium thiosulphate (STS) in an Austrian cohort of calciphylaxis patients.

Vaccination against Feline Panleukopenia: implications from a field study in kittens

Background Feline Panleukopenia (FPL) is a serious disease of cats that can be prevented by vaccination. Kittens are routinely vaccinated repeatedly during their first months of life. By this time maternally derived antibodies (MDA) can interfere with vaccination and inhibit the development of active immunity. The efficacy of primary vaccination under field conditions was...

The Core Protein of Classical Swine Fever Virus Is Dispensable for Virus Propagation In Vitro

Core protein of Flaviviridae is regarded as essential factor for nucleocapsid formation. Yet, core protein is not encoded by all isolates (GBV- A and GBV- C). Pestiviruses are a genus within the family Flaviviridae that affect cloven-hoofed animals, causing economically important diseases like classical swine fever (CSF) and bovine viral diarrhea (BVD). Recent findings describe...