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Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction

As of 2009, anticoagulation with citrate was standard practice in continuous renal replacement therapy (CRRT) for critically ill patients at the University Medical Centre of Saarland, Germany. Partial hepatic metabolism of citrate means accumulation may occur during CRRT in critically ill patients with impaired liver function. The aim of this study was to evaluate the actual ...

Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction

As of 2009, anticoagulation with citrate was standard practice in continuous renal replacement therapy (CRRT) for critically ill patients at the University Medical Centre of Saarland, Germany. Partial hepatic metabolism of citrate means accumulation may occur during CRRT in critically ill patients with impaired liver function. The aim of this study was to evaluate the actual ...

Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction

As of 2009, anticoagulation with citrate was standard practice in continuous renal replacement therapy (CRRT) for critically ill patients at the University Medical Centre of Saarland, Germany. Partial hepatic metabolism of citrate means accumulation may occur during CRRT in critically ill patients with impaired liver function. The aim of this study was to evaluate the actual ...

Occurrence and severity of non-occlusive mesenteric ischemia (NOMI) after cardiovascular surgery correlate with preoperatively assessed FGF-23 levels

Purpose To evaluate the value of preoperatively assessed fibroblast growth factor 23 (FGF-23) levels and to correlate FGF-23 with angiographic findings in non-occlusive mesenteric (NOMI) ischemia using a standardized scoring system. Materials and methods Between 2/2011 and 3/2012 a total of 865 patients (median age: 67 years) underwent cardiovascular surgery during this ethics ...

Prognostic value of procalcitonin in patients after elective cardiac surgery: a prospective cohort study

Background Procalcitonin (PCT) is a well-known prognostic marker after elective cardiac surgery. However, the impact of elevated PCT in patients with an initially uneventful postoperative course is still unclear. The aim of this study was to evaluate PCT levels as a prognostic tool for delayed complications after elective cardiac surgery. Methods A prospective study was performed ...

Acute kidney injury prediction in cardiac surgery patients by a urinary peptide pattern: a case-control validation study

Background Acute kidney injury (AKI) is a prominent problem in hospitalized patients and associated with increased morbidity and mortality. Clinical medicine is currently hampered by the lack of accurate and early biomarkers for diagnosis of AKI and the evaluation of the severity of the disease. In 2010, we established a multivariate peptide marker pattern consisting of 20 ...

The gap between calculated and actual calcium substitution during citrate anticoagulation in an immobilised patient on renal replacement therapy reflects the extent of bone loss – a case report

therapy; CVVHD: Continuous venovenous haemodialysis; HU: Hounsfield units. Competing interests Matthias Klingele received speaker fees from Fresenius Medical Care and Baxter. Danilo Fliser received

A single preoperative FGF23 measurement is a strong predictor of outcome in patients undergoing elective cardiac surgery: a prospective observational study

Klingele 0 0 Department of Internal Medicine, Nephrology and Hypertension, Saarland University Medical Centre , Kirrberger Strasse, D-66424 Homburg/Saar , Germany 1 Department of Anaesthesiology, Intensive

Total-to-ionized calcium ratio predicts mortality in continuous renal replacement therapy with citrate anticoagulation in critically ill patients

Introduction Regional citrate anticoagulation is safe, feasible and increasingly used in critically ill patients on continuous renal replacement therapy (CRRT). However, in patients with hepatic or multi-organ dysfunction, citrate accumulation may lead to an imbalance of calcium homeostasis. The study aimed at evaluating the incidence and prognostic relevance of an increased total ...

Bone and mineral diseases - 2

Introduction and Aims: KAI-4169, a novel long acting peptide agonist of the calcium sensing receptor (CaSR), is being evaluated in hemodialysis (HD) subjects as a thrice weekly intravenous (IV) treatment for chronic kidney disease-mineral and mineral bone disorder (CKD-MBD). This Phase 2 randomized, double-blind, placebo-controlled, dose escalation study, evaluated the efficacy of ...

DIALYSIS BONE DISEASE

, Germany 24 Amgen GmbH , München , Germany 25 Department of Nephrology , Beijing , China 26 Air Force General Hospital , Beijing , China 27 Air Force General Hospital , Bejing , China 28 Matthias Klingele