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Search: authors:"Matthias Majetschak"

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Effects of cognate, non-cognate and synthetic CXCR4 and ACKR3 ligands on human lung endothelial cell barrier function

content is solely the responsibility of the authors. The authors declare that they have no conflict of interest. Author Contributions Conceptualization: Brian F. Volkman, Matthias Majetschak. Formal ... analysis: You-Hong Cheng, Jonathan M. Eby, Matthias Majetschak. Funding acquisition: Matthias Majetschak. Investigation: You-Hong Cheng, Jonathan M. Eby. Methodology: Heather M. LaPorte, Brian F. Volkman

Kv7 voltage-activated potassium channel inhibitors reduce fluid resuscitation requirements after hemorrhagic shock in rats

Background Recent evidence suggests that drugs targeting Kv7 channels could be used to modulate vascular function and blood pressure. Here, we studied whether Kv7 channel inhibitors can be utilized to stabilize hemodynamics and reduce resuscitation fluid requirements after hemorrhagic shock. Methods Anesthetized male Sprague-Dawley rats were instrumented with arterial and venous...