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Plasma glutamine levels before cardiac surgery are related to post-surgery infections; an observational study

Background A low plasma glutamine level was found in 34% of patients after elective cardiothoracic surgery. This could be a result of the inflammation caused by surgical stress or the use of extracorporeal circulation (ECC). But it is also possible that plasma glutamine levels were already lowered before surgery and reflect an impaired metabolic state and a higher likelihood to ...

Plasma glutamine levels in patients after non-elective or elective ICU admission: an observational study

Koopmans 0 E. Christiaan Boerma 0 0 Department of Intensive Care, Medical Centre Leeuwarden , Leeuwarden , The Netherlands 1 Department of Clinical Chemistry, Medical Centre Leeuwarden , Leeuwarden , The

‘Sepsis-related anemia’ is absent at hospital presentation; a retrospective cohort analysis

Background Anemia is a common feature during sepsis that occurs due to iatrogenic blood loss, depression of serum iron levels and erythropoietin production, and a decreased lifespan of erythrocytes. However, these mechanisms are unlikely to play a role in anemia at the start of sepsis. Moreover, sequestration of fluids, renal failure and increase of intravascular space may ...

Microcirculatory blood flow as a tool to select ICU patients eligible for fluid therapy

Andrius Pranskunas Matty Koopmans Peter M. Koetsier Vidas Pilvinis E. Christiaan Boerma Received: 16 April 2012 Abstract Purpose: The aim of the patients. In these patients, MFI Accepted: 23 October

Microcirculatory changes during open label magnesium sulphate infusion in patients with severe sepsis and septic shock

Background Microcirculatory alterations play a pivotal role in sepsis and persist despite correction of systemic hemodynamic parameters. Therefore it seems tempting to test specific pro-microcirculatory strategies, including vasodilators, to attenuate impaired organ perfusion. As opposed to nitric oxide donors, magnesium has both endothelium-dependent and non-endothelium-dependent ...

No agreement of mixed venous and central venous saturation in sepsis, independent of sepsis origin

Introduction Controversy remains regarding the relationship between central venous saturation (ScvO2) and mixed venous saturation (SvO2) and their use and interchangeability in patients with sepsis or septic shock. We tested the hypothesis that ScvO2 does not reliably predict SvO2 in sepsis. Additionally we looked at the influence of the source (splanchnic or non-splanchnic) of ...