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Real-life data on potential drug-drug interactions in patients with chronic hepatitis C viral infection undergoing antiviral therapy with interferon-free DAAs in the PITER Cohort Study

Background There are few real-life data on the potential drug-drug interactions (DDIs) between anti-HCV direct-acting antivirals (DAAs) and the comedications used. Aim To assess the potential DDIs of DAAs in HCV-infected outpatients, according to the severity of liver disease and comedication used in a prospective multicentric study. Methods Data from patients in 15 clinical...

Incidence of DAA failure and the clinical impact of retreatment in real-life patients treated in the advanced stage of liver disease: Interim evaluations from the PITER network

, Maurizia Rossana Brunetto, Alfredo Di Leo, Teresa Antonia Santantonio, Giovanni Raimondo, Carmine Coppola, Pierluigi Blanc, Liliana Chemello, Filomena Morisco, Maria Grazia Rumi, Antonio Gasbarrini, Marco ... . Writing ± review & editing: Giovanni Battista Gaeta, Maurizia Rossana Brunetto, Anna Linda 11 / 13 12 / 13 1. WHO. Hepatitis C. Fact sheet updated April 2017 . Available from:

A Serum MicroRNA Signature Is Associated with the Immune Control of Chronic Hepatitis B Virus Infection

Background and Aims The virus/host interplay mediates liver pathology in chronic HBV infection. MiRNAs play a pivotal role in virus/host interactions and are detected in both serum and HBsAg-particles, but studies of their dynamics during chronic infection and antiviral therapy are missing. We studied serum miRNAs during different phases of chronic HBV infection and antiviral...

Total Hepatitis B Core Antigen Antibody, a Quantitative Non-Invasive Marker of Hepatitis B Virus Induced Liver Disease

, University Hospital of Pisa , Pisa, Italy, 3 Digestive and Liver Disease , General Medicine II Unit, University Hospital of Pisa , Pisa , Italy 1 Competing Interests: Maurizia Rossana Brunetto: invited speaker