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Search: authors:"Md Aftab Alam"

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Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles

BackgroundDoxorubicin hydrochloride (DOX·HCl), an anthracycline glycoside antibiotic, exhibits low oral bioavailability due to active efflux from intestinal P-glycoprotein receptors. The oral administration of DOX remains a challenge hence; no oral formulation for DOX is marketed, till date.Aim of the studyTo improve the oral bioavailability of DOX through, preparation of a...