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Lipocalin 2: a potential therapeutic target for breast cancer metastasis

Lipocalin 2: a potential therapeutic target for breast cancer metastasis Chenxia Hu,1 Ke Yang,1 Mengjie Li,1 Weiping Huang,2 Fengxue Zhang,2 Hongqi Wang2 1School of Pharmaceutical Science, Guangzhou

Metabolic Perturbation and Potential Markers in Patients with Esophageal Cancer

, and Jin Xu handled the specimens for screening, data collection, and critical review of the manuscript. Linsheng Liu, Mengjie Li, and Jian Shi are assigned to data collection, statistical analysis, and

Fish oil diet may reduce inflammatory levels in the liver of middle-aged rats

Innovation Center of Meat Production and Processing, Nanjing Agricultural University, Nanjing, 210095, P.R. ChinaYingqiu Li, Fan Zhao, Qiayu Wu, Mengjie Li, Yingying Zhu, Shangxin Song, Jing Zhu, Yafang Ma, He ... Scholar Search for Qiayu Wu in:Nature Research journals • PubMed • Google Scholar Search for Mengjie Li in:Nature Research journals • PubMed • Google Scholar Search for Yingying Zhu in:Nature Research

Estimation of tulathromycin depletion in plasma and milk after subcutaneous injection in lactating goats using a nonlinear mixed-effects pharmacokinetic modeling approach

Background Extra-label use of tulathromycin in lactating goats is common and may cause violative residues in milk. The objective of this study was to develop a nonlinear mixed-effects pharmacokinetic (NLME-PK) model to estimate tulathromycin depletion in plasma and milk of lactating goats. Eight lactating goats received two subcutaneous injections of 2.5 mg/kg tulathromycin 7...

Molecular survey of Enterocytozoon bieneusi in sheep and goats in China

Background Over recent years, several studies have conducted genotyping of Enterocytozoon bieneusi in various hosts worldwide using sequence analysis of the ribosomal internal transcribed spacer (ITS), however, relatively little is known about E. bieneusi in sheep and goats in China. Therefore this research was conducted to understand the prevalence and genotype distribution of E...

Familial Risks and Estrogen Receptor-Positive Breast Cancer in Hong Kong Chinese Women

Purpose The role of family history to the risk of breast cancer was analyzed by incorporating menopausal status in Hong Kong Chinese women, with a particular respect to the estrogen receptor-positive (ER+) type. Methods Seven hundred and forty seven breast cancer incident cases and 781 hospital controls who had completed information on family cancer history in first-degree...

Metabolomic approach to evaluating adriamycin pharmacodynamics and resistance in breast cancer cells

Continuous exposure of breast cancer cells to adriamycin induces high expression of P-gp and multiple drug resistance. However, the biochemical process and the underlying mechanisms for the gradually induced resistance are not clear. To explore the underlying mechanism and evaluate the anti-tumor effect and resistance of adriamycin, the drug-sensitive MCF-7S and the drug...

Prediction of the Pharmacokinetic Parameters of Triptolide in Rats Based on Endogenous Molecules in Pre-Dose Baseline Serum

Background Individual variances usually affect drug metabolism and disposition, and hence result in either ineffectiveness or toxicity of a drug. In addition to genetic polymorphism, the multiple confounding factors of lifestyles, such as dietary preferences, contribute partially to individual variances. However, the difficulty of quantifying individual diversity greatly...

Chronic Myeloid Leukemia Patients Sensitive and Resistant to Imatinib Treatment Show Different Metabolic Responses

The BCR-ABL tyrosine kinase inhibitor imatinib is highly effective for chronic myeloid leukemia (CML). However, some patients gradually develop resistance to imatinib, resulting in therapeutic failure. Metabonomic and genomic profiling of patients' responses to drug interventions can provide novel information about the in vivo metabolism of low-molecular-weight compounds and...