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Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels

-rectifying potassium channel 6; NBD, nucleotide binding domain; SUR, sulfonylurea receptor; TMD0-L0, transmembrane domain 0-loop 0 COMPLIANCE WITH ETHICS GUIDELINES Jing-Xiang Wu, Dian Ding, Mengmeng Wang ... CONTRIBUTIONS Lei Chen initiated the project. Jiang-Xiang Wu, Dian Ding, Mengmeng Wang, Yunlu Kang, Xin Zeng and Lei Chen designed experiments. Jiang-Xiang Wu prepared the cryo-EM sample. Jiang-Xiang Wu

Study of retina and choroid biological parameters of rhesus monkeys eyes on scleral collagen cross-linking by riboflavin and ultraviolet A

measurement and analysis of the IOP and OCT images used in this study. Methodology: Mingshen Sun, Bowen Ouyang, Mengmeng Wang, Yu Li, Xuan Jiao, Li Zhang. Project administration: Mingshen Sun, Fengju Zhang

Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices

coordinates (migration velocities). Branching and anastomosis may also be predicted, since these are processes often accompanied with cell phenotypic changes. Conceptualization: Mengmeng Wang, Lee-Ling Sharon ... Ong, Justin Dauwels, H. Harry Asada. 26 / 30 Data curation: Mengmeng Wang, Lee-Ling Sharon Ong. Formal analysis: Mengmeng Wang. Funding acquisition: Justin Dauwels, H. Harry Asada. Investigation

Allelopathic effect boosts Chrysosporum ovalisporum dominance in summer at the expense of Microcystis panniformis in a shallow coastal water body

The increased occurrence of harmful cyanobacterial species and, with this, higher frequency of cyanobacteria blooms, closely associated with eutrophication and climate change, have attracted increasing attention worldwide. However, competition mechanisms between the different bloom-forming cyanobacteria species remain to be elucidated. In this paper, for the first time, the...

Effects of scleral cross-linking using genipin on the process of form-deprivation myopia in the guinea pig: a randomized controlled experimental study

Background Scleral cross-linking (CXL) is a novel attempt to slow down the axial elongation process in animal eyes. As a natural CXL reagent, genipin would be also effective for the prevention of myopia process. Thus, the present study was designed to evaluate the effects of scleral cross-linking using genipin on the form-deprivation (FD) myopia process of guinea pigs. Methods...

Pathogenic variants screening in seventeen candidate genes on 2p15 for association with ankylosing spondylitis in a Han Chinese population

Objectives Previous studies have found the association between rs10865331 in 2p15 area and ankylosing spondylitis (AS). This study aimed to identify additional functional genetic variants in 2p15 region associated with AS susceptibility. Methods We used next generation sequencing (NGS) in 100 AS cases and 100 healthy controls to screen AS susceptible genetic variants, and...

An efficient source of frequency anti-correlated entanglement at telecom wavelength

We demonstrate an efficient generation of frequency anti-correlated entangled photon pairs at telecom wavelength. The fundamental laser is a continuous-wave high-power fiber laser at 1560 nm, through an extracavity frequency doubling system, a 780-nm pump with a power as high as 742 mW is realized. After single-passing through a periodically poled KTiOPO4 (PPKTP) crystal...

Analysis on the situation of subjective well-being and its influencing factors in patients with ankylosing spondylitis

Background To examine the subjective well-being (SWB) in patients with ankylosing spondylitis (AS) compared with the healthy controls, and to explore the associations between SWB and demographic characteristics, disease-specific variables in AS patients. Methods SWB was assessed with General Well-Being Schedule (GWBS) in 200 AS patients and 210 healthy controls. Comparisons among...

Combination Therapy of Sorafenib and TACE for Unresectable HCC: A Systematic Review and Meta-Analysis

Background and Aim A large number of studies have tried to combine sorafenib with TACE for patients with unresectable hepatocellular carcinoma (HCC) and the results were controversial. We conducted this systematic review and meta-analysis to evaluate the safety and efficacy of combination therapy of sorafenib and TACE in the management of unresectable HCC. Methods MEDLINE...

Extending the Good Diet, Good Health Paradigm: Modulation of Breast Cancer Resistance Protein (BCRP) by Flavonoids

Mengmeng Wang 0 0 Department of Metabolism and Pharmacokinetics, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Pharmaceutical Research Institute , Pennington, NJ 08534 The Author 2007

Secretome diversity and quantitative analysis of cellulolytic Aspergillus fumigatus Z5 in the presence of different carbon sources

Background Aspergillus fumigatus Z5 has a strong ability to decompose lignocellulose biomass, and its extracellular protein secretion has been reported in earlier studies employing traditional techniques. However, a comprehensive analysis of its secretion in the presence of different carbon sources is still lacking. The goal of this work was to identify, quantify and compare the...

Degradation of aqueous synthesized CdTe/ZnS quantum dots in mice: differential blood kinetics and biodistribution of cadmium and tellurium

Background Quantum dots (QDs) have been used as novel fluorescent nanoprobes for various bioapplications. The degradation of QDs, and consequent release of free cadmium ions, have been suggested to be the causes of their overall toxicity. However, in contrast to sufficient investigations regarding the biological fate of QDs, a paucity of studies have reported their chemical fate...