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The DNA methylation profile of non-coding RNAs improves prognosis prediction for pancreatic adenocarcinoma

Compelling lines of evidence indicate that DNA methylation of non-coding RNAs (ncRNAs) plays critical roles in various tumour progression. In addition, the differential methylation of ncRNAs can predict prognosis of patients. However, little is known about the clear relationship between DNA methylation profile of ncRNAs and the prognosis of pancreatic adenocarcinoma (PAC...

HNRNPA2B1 regulates the epithelial–mesenchymal transition in pancreatic cancer cells through the ERK/snail signalling pathway

Background Heterogeneous nuclear ribonucleoprotein A2B1 (HNRNPA2B1) is closely related to tumour occurrence and development, oncogene expression, apoptosis inhibition and invasion and metastasis capacities. However, its function in the epithelial–mesenchymal transition (EMT) of pancreatic cancer is not fully understood. Methods By comparing various wild-type pancreatic cancer...

HNRNPA2B1 regulates the epithelial–mesenchymal transition in pancreatic cancer cells through the ERK/snail signalling pathway

, Shihao Huang1, Bin Lou1, Binbo Fang1, Tingting Ye1, Xince Huang1, Bicheng Chen†1, 2Email author and Mengtao Zhou†1Email author †Contributed equally Cancer Cell International201717:12 https://doi.org ... understanding of HNRNPA2B1’s regulation of EMT and its potential signalling pathway. Notes Mengtao Zhou, Bicheng Chen and Shengjie Dai contributed equally to this work Abbreviations EMT:  epithelial