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Eucommia ulmoides Cortex, Geniposide and Aucubin Regulate Lipotoxicity through the Inhibition of Lysosomal BAX

In this study we examined the inhibition of hepatic dyslipidemia by Eucommia ulmoides extract (EUE). Using a screening assay for BAX inhibition we determined that EUE regulates BAX-induced cell death. Among various cell death stimuli tested EUE regulated palmitate-induced cell death, which involves lysosomal BAX translocation. EUE rescued palmitate-induced inhibition of lysosomal...

Eucommia ulmoides Oliver Extract, Aucubin, and Geniposide Enhance Lysosomal Activity to Regulate ER Stress and Hepatic Lipid Accumulation

Eucommia ulmoides Oliver is a natural product widely used as a dietary supplement and medicinal plant. Here, we examined the potential regulatory effects of Eucommia ulmoides Oliver extracts (EUE) on hepatic dyslipidemia and its related mechanisms by in vitro and in vivo studies. EUE and its two active constituents, aucubin and geniposide, inhibited palmitate-induced endoplasmic...

The protective role of Bax Inhibitor-1 against chronic mild stress through the inhibition of monoamine oxidase A

National University Medical School, Jeonju, KoreaHwa-Young Lee, Geum-Hwa Lee, Anu Marahatta, Shun-Mei Lin, Mi-Rin Lee & Han-Jung ChaeDepartment of Pathology, Chonbuk National University Medical School ... for Mi-Rin Lee in:Nature Research journals • PubMed • Google ScholarSearch for Kyu Yun Jang in:Nature Research journals • PubMed • Google ScholarSearch for Kyung Min Kim in:Nature Research journals