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Search: authors:"Michał Myśliwiec"

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Indoxyl sulfate – the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease

Background During chronic kidney disease progression, kidney-specific risk factors for cardiovascular disease come into play. The present study investigated the impact of indoxyl sulfate, dietary tryptophan-derived uremic toxin, accumulated in the blood of patients with chronic kidney disease on hemostatic parameters, markers of inflammation, oxidative stress and monocyte to ...

Serum hepatocyte growth factor is associated with viral hepatitis, cardiovascular disease, erythropoietin treatment, and type of heparin in haemodialysis patients

Background. Increased serum hepatocyte growth factor (HGF) level is a part of the counter‐system against tissue damage and predicts mortality in maintenance haemodialysis (HD) patients. We studied which of the common co‐morbid and clinical conditions, and surrogates of metabolic disorders or specific organ damage determine HGF levels in these subjects. Methods. In 86 patients, ...

Enoxaparin but not unfractionated heparin causes a dose-dependent increase in plasma TGF-β1 during haemodialysis: a cross-over study

Background. Transforming growth factor-β1 (TGF-β1) is a multi-functional cytokine that presents as a mediator of the heparin's pleiotropic action. In this cross-over study, we compared the effects of enoxaparin and unfractionated heparin (UFH) used as anticoagulants during haemodialysis (HD) on plasma TGF-β1 levels and some platelet activation markers: platelet-derived growth ...

The periodontal status of pre-dialysis chronic kidney disease and maintenance dialysis patients

Background. Periodontitis contributes to generalized inflammation and development of systemic diseases, including atherosclerosis and cardiovascular disease. Its extent in maintenance haemodialysis (HD) patients is disputable and not known in continuous ambulatory peritoneal dialysis (CAPD) and pre-dialysis chronic kidney disease (CKD) patients. Methods. One hundred and six ...

Different effects of enoxaparin and unfractionated heparin on extrinsic blood coagulation during haemodialysis: a prospective study

Background. Heparin inhibits prothrombotic tissue factor (TF) and releases its inhibitor, tissue factor pathway inhibitor (TFPI), from the endothelium, but repeated administration of heparin depletes vascular stores of TFPI. We studied the anticoagulant effects of unfractionated heparin (UFH) vs low‐molecular‐weight enoxaparin—used for thrice‐weekly maintenance haemodialysis ...

Soluble thrombomodulin is associated with viral hepatitis, blood pressure, and medications in haemodialysis patients

Background. The level of soluble thrombomodulin (sTM), a traditional marker of endothelial injury, is also dependent on renal excretory function. We studied serum sTM in chronic haemodialysis (HD) patients to determine which factors are predictive of its levels in this population. Methods and results. sTM levels of 10.7 (5.72–30.7) ng/ml in 100 HD patients were higher than in 30 ...