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Could Alzheimer’s Disease Originate in the Periphery and If So How So?

The classical amyloid cascade model for Alzheimer’s disease (AD) has been challenged by several findings. Here, an alternative molecular neurobiological model is proposed. It is shown that the presence of the APOE ε4 allele, altered miRNA expression and epigenetic dysregulation in the promoter region and exon 1 of TREM2, as well as ANK1 hypermethylation and altered levels of...

Multiple Immune-Inflammatory and Oxidative and Nitrosative Stress Pathways Explain the Frequent Presence of Depression in Multiple Sclerosis

Patients with a diagnosis of multiple sclerosis (MS) or major depressive disorder (MDD) share a wide array of biological abnormalities which are increasingly considered to play a contributory role in the pathogenesis and pathophysiology of both illnesses. Shared abnormalities include peripheral inflammation, neuroinflammation, chronic oxidative and nitrosative stress...

A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause?

There is copious evidence of abnormalities in resting-state functional network connectivity states, grey and white matter pathology and impaired cerebral perfusion in patients afforded a diagnosis of multiple sclerosis, major depression or chronic fatigue syndrome (CFS) (myalgic encephalomyelitis). Systemic inflammation may well be a major element explaining such findings. Inter...

Cognitive functioning following stabilisation from first episode mania

Griffiths Fellowship, The University of Melbourne. Murat Yücel is supported by a NHMRC Senior Research Fellowship 1021973. Michael Berk is supported by a NHMRC Senior Principal Research Fellowship 1059660

Online ethics: where will the interface of mental health and the internet lead us?

While e-health initiatives are poised to revolutionize delivery and access to mental health care, conducting clinical research online involves specific contextual and ethical considerations. Face-to-face psychosocial interventions can at times entail risk and have adverse psychoactive effects, something true for online mental health programs too. Risks associated with and...

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders

Background Mitochondrial dysfunction and defects in oxidative metabolism are a characteristic feature of many chronic illnesses not currently classified as mitochondrial diseases. Examples of such illnesses include bipolar disorder, multiple sclerosis, Parkinson’s disease, schizophrenia, depression, autism, and chronic fatigue syndrome. Discussion While the majority of patients...

Immuno-psychiatry: an agenda for clinical practice and innovative research

Background The diagnostic scheme for psychiatric disorders is currently based purely on descriptive nomenclature given that biomarkers subtypes and clearly defined causal mechanisms are lacking for the vast majority of disorders. The emerging field of “immuno-psychiatry” has the potential to widen the exploration of a mechanism-based nosology, possibly leading to the discovery of...

Into the Bowels of Depression: Unravelling Medical Symptoms Associated with Depression by Applying Machine-Learning Techniques to a Community Based Population Sample

Learning for Assistive Technologies: 45. 18. Joanna F Dipnall JAP , Michael Berk , Lana J Williams , Seetal Dodd,Felice, N Jacka DM ( 2016 ) Why so GLUMM? Detecting depression clusters through Graphing

The DSM-5: Hyperbole, Hope or Hypothesis?

School of Medicine, Deakin University , Barwon Health, Ryrie Street, Geelong, VIC 3220 , Australia 2 Competing interests Michael Berk has received Grant/Research Support from the NIH, Cooperative Research

A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial)

Bipolar and Depressive Disorders and Servier. She has also received in-kind support from BioMedica Nutracuticals, NutritionCare and Bioceuticals. Michael Berk has received Grant/Research Support from the

Pathways to new drug discovery in neuropsychiatry

There is currently a crisis in drug discovery for neuropsychiatric disorders, with a profound, yet unexpected drought in new drug development across the spectrum. In this commentary, the sources of this dilemma and potential avenues to redress the issue are explored. These include a critical review of diagnostic issues and of selection of participants for clinical trials, and the...

Cognitive remission: a novel objective for the treatment of major depression?

8 Brisa S. Fernandes 4 6 8 Michael Berk 4 5 8 André F. Carvalho 0 1 4 0 Translational Psychiatry Research Group and Department of Clinical Medicine, Faculty Medicine, Federal University of Ceará

Oxidant/antioxidant imbalance is an inherent feature of depression

Background 50% to 60% of the people who have recovered from the first episode of depression experience a relapse. The immune system of the people suffering from depression is in a permanent state of pathological pro-inflammatory readiness. There are some reports that depressive episodes cause sensitization of immune-inflammatory pathways and that staing of depression (e.g. number...

The Post-Anaesthesia N-acetylcysteine Cognitive Evaluation (PANACEA) trial: study protocol for a randomised controlled trial

Background Some degree of cognitive decline after surgery occurs in as many as one quarter of elderly surgical patients, and this decline is associated with increased morbidity and mortality. Cognition may be affected across a range of domains, including memory, psychomotor skills, and executive function. Whilst the exact mechanisms of cognitive change after surgery are not...

Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses

Gerwyn Morris Michael Berk 0 1 Ken Walder Michael Maes 1 0 Department of Psychiatry and The Florey Institute of Neuroscience and Mental Health , Orygen , The National Centre of Excellence in Youth

Evaluating discussion board engagement in the MoodSwings online self-help program for bipolar disorder: protocol for an observational prospective cohort study

Gliddon, BAppSci(Psych), BSci(Hons) Contact for scientific queries Prof Michael Berk, FFPsych, PhD Primary registry and trial identifying number Source(s) of monetary or material support Countries of

Construct validity of the Experiences of Therapy Questionnaire (ETQ)

Background The Experiences of Therapy Questionnaire (ETQ) is a reliable measure of adverse effects associated with psychotherapy. The measure has not been subject to validity analyses. This study sought to examine the validity of the ETQ by comparison against a measure of therapist satisfaction. Methods Participants were recruited from the Black Dog Institute’s website and...

Fusing Data Mining, Machine Learning and Traditional Statistics to Detect Biomarkers Associated with Depression

explains the NHANES biomarker variables used for this study and references key NHANES analytical information. Funding: Michael Berk is supported by a NHMRC Senior Principal Research Fellowship 1059660 and

The effects of escitalopram on myocardial apoptosis and the expression of Bax and Bcl-2 during myocardial ischemia/reperfusion in a model of rats with depression

; BH1: Bcl-2 homology 1; BH2: Bcl-2 homology 1. Competing interests Michael Berk has received Grant/Research Support from the NIH, Cooperative Research Centre, Simons Autism Foundation, Cancer Council of

Excessive daytime sleepiness and falls among older men and women: cross-sectional examination of a population-based sample

. Michael Berk is supported by a NHMRC Senior Principal Research Fellowship 1059660 and has received Grant/Research Support from the NIH, Simons Foundation, CRC for Mental Health, Stanley Medical Research