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A randomised controlled trial of dietary improvement for adults with major depression (the ‘SMILES’ trial)

Bipolar and Depressive Disorders and Servier. She has also received in-kind support from BioMedica Nutracuticals, NutritionCare and Bioceuticals. Michael Berk has received Grant/Research Support from the

Immuno-psychiatry: an agenda for clinical practice and innovative research

Background The diagnostic scheme for psychiatric disorders is currently based purely on descriptive nomenclature given that biomarkers subtypes and clearly defined causal mechanisms are lacking for the vast majority of disorders. The emerging field of “immuno-psychiatry” has the potential to widen the exploration of a mechanism-based nosology, possibly leading to the discovery of ...

The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders

Background Mitochondrial dysfunction and defects in oxidative metabolism are a characteristic feature of many chronic illnesses not currently classified as mitochondrial diseases. Examples of such illnesses include bipolar disorder, multiple sclerosis, Parkinson’s disease, schizophrenia, depression, autism, and chronic fatigue syndrome. Discussion While the majority of patients ...

The Post-Anaesthesia N-acetylcysteine Cognitive Evaluation (PANACEA) trial: study protocol for a randomised controlled trial

Background Some degree of cognitive decline after surgery occurs in as many as one quarter of elderly surgical patients, and this decline is associated with increased morbidity and mortality. Cognition may be affected across a range of domains, including memory, psychomotor skills, and executive function. Whilst the exact mechanisms of cognitive change after surgery are not ...

N-acetylcysteine (NAC) in schizophrenia resistant to clozapine: a double blind randomised placebo controlled trial targeting negative symptoms

Paul S. Francis 14 Cherrie Galletly 12 13 Anthony Harris 11 16 Dan Siskind 15 Michael Berk 10 Kiymet Bozaoglu 6 Frances Dark 7 Olivia Dean 10 Dennis Liu 12 13 Denny Meyer 1 4 Erica Neill 0 9 Andrea ... Siskind is a consultant psychiatrist and an Associate Professor of Psychiatry; Prof Michael Berk is an NHMRC Senior Principal research Fellow, a consultant psychiatrist and Chair of Psychiatry at Barwon

Cognitive remission: a novel objective for the treatment of major depression?

8 Brisa S. Fernandes 4 6 8 Michael Berk 4 5 8 André F. Carvalho 0 1 4 0 Translational Psychiatry Research Group and Department of Clinical Medicine, Faculty Medicine, Federal University of Ceará

The DSM-5: Hyperbole, Hope or Hypothesis?

School of Medicine, Deakin University , Barwon Health, Ryrie Street, Geelong, VIC 3220 , Australia 2 Competing interests Michael Berk has received Grant/Research Support from the NIH, Cooperative Research

Fusing Data Mining, Machine Learning and Traditional Statistics to Detect Biomarkers Associated with Depression

explains the NHANES biomarker variables used for this study and references key NHANES analytical information. Funding: Michael Berk is supported by a NHMRC Senior Principal Research Fellowship 1059660 and

Evaluating discussion board engagement in the MoodSwings online self-help program for bipolar disorder: protocol for an observational prospective cohort study

Gliddon, BAppSci(Psych), BSci(Hons) Contact for scientific queries Prof Michael Berk, FFPsych, PhD Primary registry and trial identifying number Source(s) of monetary or material support Countries of

Pathways to new drug discovery in neuropsychiatry

There is currently a crisis in drug discovery for neuropsychiatric disorders, with a profound, yet unexpected drought in new drug development across the spectrum. In this commentary, the sources of this dilemma and potential avenues to redress the issue are explored. These include a critical review of diagnostic issues and of selection of participants for clinical trials, and the ...

Oxidant/antioxidant imbalance is an inherent feature of depression

Background 50% to 60% of the people who have recovered from the first episode of depression experience a relapse. The immune system of the people suffering from depression is in a permanent state of pathological pro-inflammatory readiness. There are some reports that depressive episodes cause sensitization of immune-inflammatory pathways and that staing of depression (e.g. number ...

Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses

Gerwyn Morris Michael Berk 0 1 Ken Walder Michael Maes 1 0 Department of Psychiatry and The Florey Institute of Neuroscience and Mental Health , Orygen , The National Centre of Excellence in Youth

Construct validity of the Experiences of Therapy Questionnaire (ETQ)

Background The Experiences of Therapy Questionnaire (ETQ) is a reliable measure of adverse effects associated with psychotherapy. The measure has not been subject to validity analyses. This study sought to examine the validity of the ETQ by comparison against a measure of therapist satisfaction. Methods Participants were recruited from the Black Dog Institute’s website and ...

Excessive daytime sleepiness and falls among older men and women: cross-sectional examination of a population-based sample

. Michael Berk is supported by a NHMRC Senior Principal Research Fellowship 1059660 and has received Grant/Research Support from the NIH, Simons Foundation, CRC for Mental Health, Stanley Medical Research

The effects of escitalopram on myocardial apoptosis and the expression of Bax and Bcl-2 during myocardial ischemia/reperfusion in a model of rats with depression

; BH1: Bcl-2 homology 1; BH2: Bcl-2 homology 1. Competing interests Michael Berk has received Grant/Research Support from the NIH, Cooperative Research Centre, Simons Autism Foundation, Cancer Council of

Cognitive impairment in first-episode mania: a systematic review of the evidence in the acute and remission phases of the illness

. Kelly Allott is supported by a NHMRC Clinical Research Training Fellowship 628884. Michael Berk is supported by a NHMRC Senior Principal Research Fellowship 1059660 and has received Grant/Research Support

Niacin Skin Sensitivity Is Increased in Adolescents at Ultra-High Risk for Psychosis

Background Most studies provide evidence that the skin flush response to nicotinic acid (niacin) stimulation is impaired in schizophrenia. However, only little is known about niacin sensitivity in the ultra-high risk (UHR) phase of psychotic disorders. Methods We compared visual ratings of niacin sensitivity between adolescents at UHR for psychosis according to the one year ...

A shared framework for the common mental disorders and Non-Communicable Disease: key considerations for disease prevention and control

Background Historically, the focus of Non Communicable Disease (NCD) prevention and control has been cardiovascular disease (CVD), type 2 diabetes mellitus (T2DM), cancer and chronic respiratory diseases. Collectively, these account for more deaths than any other NCDs. Despite recent calls to include the common mental disorders (CMDs) of depression and anxiety under the NCD ...

The impact of maternal smoking during pregnancy on depressive and anxiety behaviors in children: the Norwegian Mother and Child Cohort Study

Background Maternal smoking during pregnancy (MSDP) is associated with multiple adverse childhood outcomes including externalizing behaviors. However, the association between MSDP and internalizing (anxiety and depressive) behaviors in offspring has received less investigation. We aimed to assess the association between MSDP and childhood internalizing (anxiety and depressive) ...

Food policies for physical and mental health

Noncommunicable diseases (NCDs) account for the largest burden of early mortality and are predicted to cost the global community more than US $30 trillion over the next 20 years. Unhealthy dietary habits, in large part driven by substantial changes to global food systems, are recognised as major contributors to many of the common NCDs, including cardiovascular disease, cancer and ...