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Differential effects of ongoing EEG beta and theta power on memory formation

Recently, elevated ongoing pre-stimulus beta power (13–17 Hz) at encoding has been associated with subsequent memory formation for visual stimulus material. It is unclear whether this activity is merely specific to visual processing or whether it reflects a state facilitating general memory formation, independent of stimulus modality. To answer that question, the present study ...

Danish translation and linguistic validation of the BODY-Q: a description of the process

Background Patient-reported outcome (PRO) instruments are increasingly being included in research and clinical practice to assess the patient point of view. Bariatric and body contouring surgery has the potential to improve or restore a patient’s body image and health-related quality of life (HR-QOL). A new PRO instrument, called the BODY-Q, has recently been developed specifically ...

How to select outcome measurement instruments for outcomes included in a “Core Outcome Set” – a practical guideline

Background In cooperation with the Core Outcome Measures in Effectiveness Trials (COMET) initiative, the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) initiative aimed to develop a guideline on how to select outcome measurement instruments for outcomes (i.e., constructs or domains) included in a “Core Outcome Set” (COS). A COS is an agreed ...

LacaScore: a novel plasma sample quality control tool based on ascorbic acid and lactic acid levels

Introduction Metabolome analysis is complicated by the continuous dynamic changes of metabolites in vivo and ex vivo. One of the main challenges in metabolomics is the robustness and reproducibility of results, partially driven by pre-analytical variations. Objectives The objective of this study was to analyse the impact of pre-centrifugation time and temperature, and to determine ...

A Prospective Randomized Comparison using MRI of Two Distinct Allogenic Tissue Constructs for Anterior Cruciate Ligament Reconstruction

Objectives: To compare the radiographic and clinical outcomes of anterior cruciate ligament (ACL) reconstruction using quadrupled hamstring tendon (HT) allograft vs. doubled tibialis anterior (TA) allograft.

A constrained generalised- \(\alpha \) method for coupling rigid parallel chain kinematics and elastic bodies

A problem arises from combining flexible rotorcraft blades with stiffer mechanical links, which form a parallel kinematic chain. This paper introduces a method for solving index-3 differential algebraic equations for coupled stiff and elastic body systems with closed-loop kinematics. Rigid body dynamics and elastic body mechanics are independently described according to convenient ...

Surgical strategy, methods of reconstruction, surgical margins and postoperative complications in oncoplastic breast surgery

Background Oncoplastic breast surgery is an evolving discipline in the surgical treatment of breast cancer aimed to improve the outcome. Methods Oncoplastic breast surgery was performed between January 2008 and December 2010 on 72 women with 74 breast cancers selected from a population of 1,018 primary breast cancer patients. Careful preoperative planning revealed the possibility ...

Epigenetic inactivation of ST6GAL1 in human bladder cancer

authors read, critically revised, and approved the final manuscript. Authors’ information Pia Antony and Michael Rose are equal first authors. Nadine T Gaisa and Edgar Dahl are equal co-senior authors

Extracellular cyclophilin A possesses chemotaxic activity in cattle

Cyclophilin A (CyPA) was originally discovered in bovine thymocytes as a cytosolic binding protein of the immunosuppressive drug cyclosporine A. Recent studies have revealed that in mice and humans, CyPA is secreted from cells in injured or infected tissues and plays a role in recruiting inflammatory cells in those tissues. Here we found that in cattle abundant level of ...

BDNF Is Associated with SFRP1 Expression in Luminal and Basal-Like Breast Cancer Cell Lines and Primary Breast Cancer Tissues: A Novel Role in Tumor Suppression?

Secreted frizzled related protein 1 (SFRP1) functions as an important inhibitor of the Wnt pathway and is a known tumor suppressor gene, which is epigenetically silenced in a variety of tumors e.g. in breast cancer. However, it is still unclear how SFRP1 exactly affects the Wnt pathway. Our aim was to decipher SFRP1 involvement in biochemical signaling in dependency of different ...

AGR3 in Breast Cancer: Prognostic Impact and Suitable Serum-Based Biomarker for Early Cancer Detection

Blood-based early detection of breast cancer has recently gained novel momentum, as liquid biopsy diagnostics is a fast emerging field. In this study, we aimed to identify secreted proteins which are up-regulated both in tumour tissue and serum samples of breast cancer patients compared to normal tissue and sera. Based on two independent tissue cohorts (n = 75 and n = 229) and one ...

Functional Dissociation of Ongoing Oscillatory Brain States

The state of a neural assembly preceding an incoming stimulus is assumed to modulate the processing of subsequently presented stimuli. The nature of this state can differ with respect to the frequency of ongoing oscillatory activity. Oscillatory brain activity of specific frequency range such as alpha (8–12 Hz) and gamma (above 30 Hz) band oscillations are hypothesized to play a ...

The Emergence of Explicit Memory during Learning

In incidental learning situations, contingencies are extracted from the environment without the intention to learn and can change behavior without awareness for the extracted regularity. The development of explicit access to the learned regularity is an important learning mechanism that is rarely examined. With a series of behavioral, electroencephalography (EEG) and functional ...

Registry of Outcome Measures (ROM); tools supporting review and selection of outcome measures (OMs) for studies and trials

Joanne Auld 0 Michael Rose 0 Reza Seyedsadjadi 0 0 TREAT-NMD & King's College London Room 91.23 , 9th Floor, Ruskin Wing , King's College Hospital , Denmark Hill, London SE5 9RS , UK Conclusion

Epigenetic inactivation of ITIH5 promotes bladder cancer progression and predicts early relapse of pT1 high-grade urothelial tumours

Inter-α-trypsin inhibitor heavy chain 5 (ITIH5) has been associated with tumour suppression in various cancers. However, its putative role in bladder cancer is completely unknown. Therefore, we initiated a study analysing ITIH5 expression as well as its prognostic and functional impact on human urothelial cancers (UCs). Expression analysis showed a clear down-regulation of ITIH5 ...

Integration of Local Features to a Global Percept by Neural Coupling

The integration of different visual attributes into the percept of a single global shape is a central aspect of object processing. In hierarchically organized stimuli with local and global levels, the attentional focus largely determines which level is processed. Here we tested the hypothesis that object processing during attention to the global aspect of the stimulus is ...

The Functional and Temporal Characteristics of Top-down Modulation in Visual Selection

School , Germany 1 Michael Rose , Carmen Schmid, Almut Winzen, Tobias Sommer and Christian Bu ̈ chel Perceptual load of an attended task influences the processing of irrelevant background stimuli. In a ... this paper. This work was supported by the Volkswagen-Stiftung, DFG and BMBF. Address correspondence to Dr Michael Rose, NeuroImage Nord, Department of Neurology, Hamburg University Medical School

γ-Glutamyl Transpeptidase Mediation of Tumor Glutathione Utilization In Vivo

Background Glutathione is a tripeptide used by cells to protect against oxidative and free radical damage. It may also be involved in biochemical mechanisms that cause some tumors to become resistant to anticancer drugs. γ-Glutamyl transpeptidase (GGTP) is a membrane-bound enzyme that cleaves extracellular glutathione, providing cells with amino acids necessary for intracellular ...