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New Avenues for Nanoparticle-Related Therapies

contributed equally to this work. Both authors read and approved the final manuscript. Authors’ Information Michael Zhao received his BSc degree from McGill University. He was a graduate student in Dr. Mingyao

Cancer Cells Hijack PRC2 to Modify Multiple Cytokine Pathways

Polycomb Repressive Complex 2 (PRC2) is an epigenetic regulator induced in many cancers. It is thought to drive tumorigenesis by repressing division, stemness, and/or developmental regulators. Cancers evade immune detection, and diverse immune regulators are perturbed in different tumors. It is unclear how such cell-specific effects are coordinated. Here, we show a profound and...

Transient protein-protein interface prediction: datasets, features, algorithms, and the RAD-T predictor

Background Transient protein-protein interactions (PPIs), which underly most biological processes, are a prime target for therapeutic development. Immense progress has been made towards computational prediction of PPIs using methods such as protein docking and sequence analysis. However, docking generally requires high resolution structures of both of the binding partners and...