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Association of Genetic Variation in Adaptor Protein APPL1/APPL2 Loci with Non-Alcoholic Fatty Liver Disease

The importance of genetics and epigenetic changes in the pathogenesis of non alcoholic fatty liver disease (NAFLD) has been increasingly recognized. Adiponectin has a central role in regulating glucose and lipid metabolism and controlling inflammation in insulin-sensitive tissues and low adiponectin levels have been linked to NAFLD. APPL1 and APPL2 are adaptor proteins that...

Awaking Blood Pressure Surge and Progression to Microalbuminuria in Type 2 Normotensive Diabetic Patients

; Accepted 25 November 2015 Academic Editor: Bernard Portha Copyright © 2016 Michelangela Barbieri et al. This is an open access article distributed under the Creative Commons Attribution License, which ... paper. Michelangela Barbieri and Ilaria Fava researched data and contributed discussion. Acknowledgment The authors would like to thank the guarantor Professor Raffaele Marfella. References J. R

Bariatric Surgery Reduces Oxidative Stress by Blunting 24-h Acute Glucose Fluctuations in Type 2 Diabetic Obese Patients

RAFFAELE MARFELLA PHD MICHELANGELA BARBIERI PHD ROBERTO RUGGIERO MARIA ROSARIA RIZZO PHD RODOLFO GRELLA PHD ANNA LICIA MOZZILLO LUDOVICO DOCIMO GIUSEPPE PAOLISSO PHD OBJECTIVE We evaluated the

Cardiac Resynchronization Therapy Outcomes in Type 2 Diabetic Patients: Role of MicroRNA Changes

Heart failure (HF) and type 2 diabetes mellitus (T2DM) are two growing and related diseases in general population and particularly in elderly people. In selected patients affected by HF and severe dysfunction of left ventricle ejection fraction (LVEF), with left bundle brunch block, the cardiac resynchronization therapy with a defibrillator (CRT) is the treatment of choice to...

Cytokine Milieu Tends Toward Inflammation in Type 2 Diabetes

ESPOSITO, MD FRANCESCO NAPPO, MD, PHD FRANCESCO GIUGLIANO CARMEN DI PALO MYRIAM CIOTOLA MICHELANGELA BARBIERI, MD GIUSEPPE PAOLISSO, MD DARIO GIUGLIANO, MD, PHD

Dipeptidyl Peptidase 4 Inhibition May Facilitate Healing of Chronic Foot Ulcers in Patients with Type 2 Diabetes

 Michelangela Barbieri,1 Vincenzo Padovano,3 Ornella Carbonara,2 Pasquale Gualdiero,1 Pasquale Petronella,3 Franca Ferraraccio,4,5 Antonello Petrella,4,5 Raffaele Canonico,3 Ferdinando Campitiello,3 Angela Della

Effects of PPARs Agonists on Cardiac Metabolism in Littermate and Cardiomyocyte-Specific PPAR-γ –Knockout (CM-PGKO) Mice

Understanding the molecular regulatory mechanisms controlling for myocardial lipid metabolism is of critical importance for the development of new therapeutic strategies for heart diseases. The role of PPARγ and thiazolidinediones in regulation of myocardial lipid metabolism is controversial. The aim of our study was to assess the role of PPARγ on myocardial lipid metabolism and...

Mediterranean Diet, Telomere Maintenance and Health Status among Elderly

Leukocyte telomere length (LTL) and rate of telomere shortening are known biomarkers of aging while, numerous studies showed that Mediterranean diet (MD) may boost longevity. We studied association between telomere length, telomerase activity and different adherence to MD and its effects on healthy status. The study was conducted in 217 elderly subjects stratified according...

Reduction of Oxidative Stress and Inflammation by Blunting Daily Acute Glucose Fluctuations in Patients With Type 2 Diabetes: Role of dipeptidyl peptidase-IV inhibition

MARIA ROSARIA RIZZO PHD MICHELANGELA BARBIERI PHD RAFFAELE MARFELLA PHD GIUSEPPE PAOLISSO PHD OBJECTIVEdEvaluate the effects of two dipeptidyl peptidase-IV (DPP-4) inhibitors, sitagliptin and

Relationships Between Daily Acute Glucose Fluctuations and Cognitive Performance Among Aged Type 2 Diabetic Patients

MARIA ROSARIA RIZZO PHD RAFFAELE MARFELLA PHD MICHELANGELA BARBIERI PHD VIRGINIA BOCCARDI FRANCESCO VESTINI BIAGIO LETTIERI SILVESTRO CANONICO GIUSEPPE PAOLISSO PHD OBJECTIVE - The mean amplitude of

Serum adiponectin levels are associated with worse cognitive function in postmenopausal women

: Pasquale De Franciscis, Michelangela Barbieri, Nicola Colacurci, Giu Formal analysis: Michelangela Barbieri, Raffaele Marfella, Maria Rosaria Rizzo. Methodology: Pasquale De Franciscis, Michelangela ... Barbieri, Stefania Leo, Anna Maria Dalise, Celestino Sardu, Maria Rosaria Rizzo. Supervision: Raffaele Marfella, Nicola Colacurci, Giuseppe Paolisso, Maria Rosaria Rizzo. Validation: Nicola Colacurci