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Search: authors:"Mieke van den Heuvel"

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Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine

Contributions Conceptualization: Nienke S. van Ditzhuijzen, Mieke van den Heuvel, Oana Sorop, Evelyn Regar. Data curation: Nienke S. van Ditzhuijzen, Oana Sorop, Jurgen Ligthart, Karen Witberg, Gijs van Soest ... . Funding acquisition: Dirk-Jan Duncker, Heleen M. M. van Beusekom. Investigation: Nienke S. van Ditzhuijzen, Mie Kurata, Mieke van den Heuvel, Evelyn Regar, Heleen M. M. van Beusekom. Methodology: Nienke

Combined Renin Inhibition/(Pro)Renin Receptor Blockade in Diabetic Retinopathy- A Study in Transgenic (mREN2)27 Rats

Dysfunction of renin-angiotensin system (RAS) contributes to the pathogenesis of diabetic retinopathy (DR). Prorenin, the precursor of renin is highly elevated in ocular fluid of diabetic patients with proliferative retinopathy. Prorenin may exert local effects in the eye by binding to the so-called (pro)renin receptor ((P)RR). Here we investigated the combined effects of the renin ...

Early Systemic Microvascular Damage in Pigs with Atherogenic Diabetes Mellitus Coincides with Renal Angiopoietin Dysbalance

Background Diabetes mellitus (DM) is associated with a range of microvascular complications including diabetic nephropathy (DN). Microvascular abnormalities in the kidneys are common histopathologic findings in DN, which represent one manifestation of ongoing systemic microvascular damage. Recently, sidestream dark-field (SDF) imaging has emerged as a noninvasive tool that enables ...

Dietary saturated fat/cholesterol, but not unsaturated fat or starch, induces C-reactive protein associated early atherosclerosis and ectopic fat deposition in diabetic pigs

Background Diabetes is thought to accelerate cardiovascular disease depending on the type of diet. This study in diabetic subjects was performed to investigate the metabolic, inflammatory and cardiovascular effects of nutritional components typically present in a Western, Mediterranean or high glycaemic diet. Methods Streptozotocin-diabetic pigs (~45 kg) were fed for 10 weeks ...