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Search: authors:"Miikka Tarkia"

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Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, 18F-labeled [Nle14,Lys40]exendin-4 analog, shows promise for clinical imaging

Background Several radiometal-labeled, exendin-based tracers that target glucagon-like peptide-1 receptors (GLP-1R) have been intensively explored for β cell imaging. The main obstacle has been the high uptake of tracer in the kidneys. This study aimed to develop a novel GLP1-R-specific tracer, with fluorine-18 attached to exendin-4, to label β cells for clinical imaging with PET...

Accuracy of echocardiographic area-length method in chronic myocardial infarction: comparison with cardiac CT in pigs

Background We evaluated echocardiographic area-length methods to measure left ventricle (LV) volumes and ejection fraction (EF) in parasternal short axis views in comparison with cardiac computed tomography (CT) in pigs with chronic myocardial infarction (MI). Methods Male farm pigs with surgical occlusion of the left anterior descending coronary artery (n = 9) or sham operation...

[18F]FDG Accumulation in Early Coronary Atherosclerotic Lesions in Pigs

Finland, University of Turku, Turku University Hospital and Åbo Akademi University. Miikka Tarkia is a PhD student supported by the Inflammation is an important contributor to atherosclerosis progression