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Perinatal outcomes after induced termination of pregnancy by methods: A nationwide register-based study of first births in Finland 1996–2013

used for termination. Author Contributions Conceptualization: Situ KC, Elina Hemminki, Mika Gissler, Reija Klemetti. Data curation: Mika Gissler. Formal analysis: Situ KC. Funding acquisition: Situ ... KC, Reija Klemetti. Investigation: Situ KC, Reija Klemetti. Methodology: Situ KC, Reija Klemetti. Project administration: Situ KC, Mika Gissler, Reija Klemetti. 8 / 10 Resources: Situ KC, Suvi M

Maternal cancer and congenital anomalies in children – a Danish nationwide cohort study

Several studies on pregnancy-associated cancers have suggested an association with congenital anomalies in offspring. Previous studies have included maternal cancers diagnosed up to 2 years after pregnancy; however, long latency periods of some cancers mean that cancers diagnosed many years postpartum might have been present during pregnancy in a preclinical state. This paper...

Maternal Smoking and the Risk of Cancer in Early Life – A Meta-Analysis

Background In spite of the well-known harmful effects on the fetus, many women continue smoking during pregnancy. Smoking as an important source of toxic chemicals may contribute to the developmental origin of diseases. Objectives The aim of this work was to pursue the possible association between maternal smoking and cancer in early life. Specifically, we wanted to identify the...

Mortality in Children Aged 0-9 Years: A Nationwide Cohort Study from Three Nordic Countries

Background Mortality in children under five years has been widely studied, whereas mortality at 5–9 years has received little attention. Using unique data from national registers in three Nordic countries, we aimed to characterize mortality directionality in children aged 0 to 9 years. Methods and Findings The cohort study included all children born in Denmark from 1973 to 2008...

Cancer Incidence among Patients with Anorexia Nervosa from Sweden, Denmark and Finland

A diet with restricted energy content reduces the occurrence of cancer in animal experiments. It is not known if the underlying mechanism also exists in human beings. To determine whether cancer incidence is reduced among patients with anorexia nervosa who tend to have a low intake of energy, we carried out a retrospective cohort study of 22 654 women and 1678 men diagnosed with...

The Association of Episiotomy with Obstetric Anal Sphincter Injury–A Population Based Matched Cohort Study

Objectives To estimate the independent association of episiotomy with obstetric anal sphincter injuries (OASIS) using first a cross-sectional and then a matched pair analysis. Design A matched cohort. Setting Data was gathered from the Finnish Medical Birth Register from 2004–2011. Population All singleton vaginal births (n = 303,758). Methods Women resulting matched pairs (n...

Mortality after Parental Death in Childhood: A Nationwide Cohort Study from Three Nordic Countries

Jiong Li and colleagues examine mortality rates in children who lost a parent before 18 years old compared with those who did not using population-based data from Denmark, Sweden, and Finland. Please see later in the article for the Editors' Summary

Variations in Multiple Birth Rates and Impact on Perinatal Outcomes in Europe

), Sophie Alexander (Belgium), Pavlos Pavlou (Cyprus), Petr Velebil (Czech Republic), Laust Mortensen (Denmark), Luule Sakkeus (Estonia), Mika Gissler (Finland), Béatrice Blondel (France), Nicholas Lack ... , Laust Hvas Mortensen, University of Copenhagen; Estonia, Luule Sakkeus, Estonian Institute for Population Studies, Tallinn University; Finland, Mika Gissler, Anna Heino, Annukka Ritvanen, THL National

Contribution of Risk Factors to Extremely, Very and Moderately Preterm Births – Register-Based Analysis of 1,390,742 Singleton Births

Background Preterm birth, defined as birth occurring before 37 weeks gestation, is one of the most significant contributors to neonatal mortality and morbidity, with long-term adverse consequences for health, and cognitive outcome. Objective The aim of the present study was to identify risk factors of preterm birth (≤36+6 weeks gestation) among singleton births and to quantify...

An International Contrast of Rates of Placental Abruption: An Age-Period-Cohort Analysis

-reproductive-health/parturientsdeliveries-and-births/perinatal-statistics-parturientsdelivers-and-newborns Contact: Mika Gissler, THL National Institute for Health and Welfare, PO BOX 30, 00271 Helsinki, Finland

The Increased Risk for Autoimmune Diseases in Patients with Eating Disorders

Objective Research suggests autoimmune processes to be involved in psychiatric disorders. We aimed to address the prevalence and incidence of autoimmune diseases in a large Finnish patient cohort with anorexia nervosa, bulimia nervosa, and binge eating disorder. Methods Patients (N = 2342) treated at the Eating Disorder Unit of Helsinki University Central Hospital between 1995...

Smoking during Pregnancy Is Associated with a Decreased Incidence of Obstetric Anal Sphincter Injuries in Nulliparous Women

Background Smoking is a modifiable lifestyle factor that has been shown to be associated with adverse perinatal outcomes and to have adverse health and dose-dependent connective tissue effects. The objective of this study was to examine whether smoking during pregnancy was associated with the incidence of obstetric anal sphincter injuries (OASIS) among six birthweight groups in...

Psychological Stress and Hospitalization for Childhood Asthma-a Nationwide Cohort Study in Two Nordic Countries

ObjectiveExposures to psychological stress in early life may contribute to the development or exacerbation of asthma. We undertook a cohort study based on data from several population-based registers in Denmark and Sweden to examine whether bereavement in childhood led to increased asthma hospitalization. MethodsAll singleton children born in Denmark during 1977-2008 and in...

The Burden of OASIS Increases along with Socioeconomic Position – Register-Based Analysis of 980,733 Births in Finland

Background Obstetric anal sphincter injury (OASIS) has been identified as a major preventable risk factor for anal incontinence. Objective Aim was to measure national variation in incidence of OASIS by socioeconomic status (SES). Methods A retrospective population based case-control study using the data derived from the Finnish Medical Birth Register for the years 1991–2010. A...

International Comparisons of Fetal and Neonatal Mortality Rates in High-Income Countries: Should Exclusion Thresholds Be Based on Birth Weight or Gestational Age?

Rigshospitalet, Copenhagen University (Denmark); Luule Sakkeus, Estonian Institute for Population Studies, Tallinn University (Estonia); Mika Gissler, THL National Institute for Health and Welfare (Finland ... Ruuge, National Institute for Health Development, Department of Health Statistics; Finland Mika Gissler, National Research and Development Centre for Welfare and Health (STAKES); Anneli Pouta National

Sex Differences in Age-Related Cardiovascular Mortality

Introduction Sex-related physiological differences result in different expressions of diseases for men and women. Data are contradicting regarding the increase in the female risk for cardiovascular disease (CVD) at mid-life. Thus, we studied possible sex differences in age-adjusted mortality for CVD and non-vascular diseases stratifying our findings by specific age groups...

Life Expectancy and Death by Diseases of the Circulatory System in Patients with Bipolar Disorder or Schizophrenia in the Nordic Countries

llgren Jeanette Westman Urban O sby Hassan Alinaghizadeh Mika Gissler Merete Nordentoft Marianna Mazza, Catholic University of Sacred Heart of Rome, Italy Objective: Excess mortality from diseases and

Infertility Treatment and Umbilical Cord Length–Novel Markers of Childhood Epilepsy?

Background Epilepsy is one of the most common neurologic disorders of childhood, affecting about 0.4−0.8% of all children up to the age of 20. Methodology A population-based retrospective cohort study. Aim was to determine incidence and identify perinatal and reproductive risk factors of epilepsy in children born between 1989 and 2008 among women (n = 43,389) delivered in Kuopio...

Excess Mortality, Causes of Death and Life Expectancy in 270,770 Patients with Recent Onset of Mental Disorders in Denmark, Finland and Sweden

, Finland and Sweden Merete Nordentoft Kristian Wahlbeck Jonas Ha llgren Jeanette Westman Urban O sby Hassan Alinaghizadeh Mika Gissler Thomas Munk Laursen Thomas Burne, University of Queensland, Australia