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Individual Participant Data (IPD) Meta-analyses of Randomised Controlled Trials: Guidance on Their Use

Jayne Tierney and colleagues offer guidance on how to spot a well-designed and well-conducted individual participant data meta-analysis.

Standardising Outcomes in Paediatric Clinical Trials

Mike Clarke discusses a new systematic review examining studies that involved the selection of outcomes for use in paediatric clinical trials. ... 0 0 Mike Clarke is at the School of Nursing and Midwifery, Trinity College Dublin , Dublin , Ireland - Whealth care of children are hether decisions about the made by parents, carers, health

Evidence for the Selective Reporting of Analyses and Discrepancies in Clinical Trials: A Systematic Review of Cohort Studies of Clinical Trials

In a systematic review of cohort studies, Kerry Dwan and colleagues examine the evidence for selective reporting and discrepancies in analyses between journal publications and other documents for clinical trials. Please see later in the article for the Editors' Summary

Doing New Research? Don't Forget the Old

Nobody should do a new research study, says Clarke, without first systematically reviewing the literature. And journal editors should insist that all research papers are accompanied by an up-to-date systematic review.

Optimal Evidence in Difficult Settings: Improving Health Interventions and Decision Making in Disasters

Martin Gerdin and colleagues argue that disaster health interventions and decision-making can benefit from an evidence-based approach Please see later in the article for the Editors' Summary

How the Cochrane Collaboration Is Responding to the Asian Tsunami

colloquia. Mike Clarke is employed as Director of the UK Cochrane Centre and to work on systematic reviews.This employment depends on the value placed on the work of the Cochrane Collaboration and systematic ... Christian Medical College in Vellore,Tamil Nadu, India, and Coordinator of the South Asian Cochrane Network. Mike Clarke is Director of the UK Cochrane Centre in Oxford, United Kingdom. Sally Green is

Is Evidence-Based Medicine Relevant to the Developing World?

Siegfried is a South African Nuffield Medical Fellow at the University of Oxford (Oxford, United Kingdom). Mike Clarke is Director of the United Kingdom Cochrane Centre (Oxford, United Kingdom).The authors ... are involved in the work of the Cochrane Collaboration, but the views expressed in this article are their own and are not necessarily those of the Cochrane Collaboration 1 , Nandi Siegfried , Mike

Can We Systematically Review Studies That Evaluate Complex Interventions?

In three Viewpoints, Sasha Shepperd and colleagues, Geoff Wong, and Aziz Sheikh explore various approaches to help systematic reviewers who wish to review complex health interventions.

CONSORT for Reporting Randomized Controlled Trials in Journal and Conference Abstracts: Explanation and Elaboration

Background Clear, transparent, and sufficiently detailed abstracts of conferences and journal articles related to randomized controlled trials (RCTs) are important, because readers often base their assessment of a trial solely on information in the abstract. Here, we extend the CONSORT (Consolidated Standards of Reporting Trials) Statement to develop a minimum list of essential ...

The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration

Alessandro Liberati and colleagues present an Explanation and Elaboration of the PRISMA Statement, updated guidelines for the reporting of systematic reviews and meta-analyses.