Systematic reviews seek to bring together research evidence to answer the question for the review. The reviewers usually wish to compare, contrast and, if appropriate, combine the findings of the existing research studies. However, these intentions are often thwarted by inconsistencies in the outcomes that were measured and reported in the individual studies. This, in turn, makes...
Systematic reviews seek to bring together research evidence to answer the question for the review. The reviewers usually wish to compare, contrast and, if appropriate, combine the findings of the existing research studies. However, these intentions are often thwarted by inconsistencies in the outcomes that were measured and reported in the individual studies. This, in turn, makes...
for Healthcare Research and Quality (Rockville, USA); Mike Clarke, Queen’s University of Belfast (Belfast, Ireland); Tammy Clifford, Canadian Agency for Drugs and Technologies in Health (CADTH) (Ottawa
Background Critically ill patients have an increased risk of developing delirium during their intensive care stay. To date, pharmacological interventions have not been shown to be effective for delirium management but non-pharmacological interventions have shown some promise. The aim of this systematic review is to identify effective non-pharmacological interventions for reducing...
Critically ill patients have an increased risk of developing delirium during their intensive care stay. To date, pharmacological interventions have not been shown to be effective for delirium management but non-pharmacological interventions have shown some promise. The aim of this systematic review is to identify effective non-pharmacological interventions for reducing the...
Background A core outcome set (COS) can address problems of outcome heterogeneity and outcome reporting bias in trials and systematic reviews, including Cochrane reviews, helping to reduce waste. One of the aims of the international Core Outcome Measures in Effectiveness Trials (COMET) Initiative is to link the development and use of COS with the outcomes specified and reported...
A core outcome set (COS) can address problems of outcome heterogeneity and outcome reporting bias in trials and systematic reviews, including Cochrane reviews, helping to reduce waste. One of the aims of the international Core Outcome Measures in Effectiveness Trials (COMET) Initiative is to link the development and use of COS with the outcomes specified and reported in Cochrane...
Mike Clarke discusses a new systematic review examining studies that involved the selection of outcomes for use in paediatric clinical trials. ... 0 0 Mike Clarke is at the School of Nursing and Midwifery, Trinity College Dublin , Dublin , Ireland - Whealth care of children are hether decisions about the made by parents, carers, health
Jayne Tierney and colleagues offer guidance on how to spot a well-designed and well-conducted individual participant data meta-analysis.
Nobody should do a new research study, says Clarke, without first systematically reviewing the literature. And journal editors should insist that all research papers are accompanied by an up-to-date systematic review.
Background PROSPERO, an international prospective register of systematic review protocols in health and social care, was launched in February 2011. After one year of operation we describe access and use, explore user experience and identify areas for future improvement. Methods We collated administrative data and web statistics and conducted an online survey of users’ experiences...
PROSPERO, an international prospective register of systematic review protocols in health and social care, was launched in February 2011. After one year of operation we describe access and use, explore user experience and identify areas for future improvement. We collated administrative data and web statistics and conducted an online survey of users’ experiences. On 21 February...
0 2 Toby Lasserson 1 Elaine Beller Margaret Carroll Vanora Hundley Judith Sunderland Declan Devane Jane Noyes Susan Key Sarah Norris Janine Wyn-Davies Mike Clarke 0 School of Nursing and Midwifery ... practice; OSCEs: objective structured clinical examinations; OR: odds ratio; RD: risk difference; 95 % CI: 95 % confidence interval. Competing interests Fiona Alderdice, Mike Clarke, Toby Lasserson, Declan
) Competing interests Fiona Alderdice, Mike Clarke, Toby Lasserson, Declan Devane, Elaine Beller, Vanora Hundley, Jane Noyes are all authors of Cochrane Reviews. Toby Lasserson is a Cochrane Review author
Systematic Reviews The nuts and bolts prospective register Booth et al. Alison Booth Mike Clarke Gordon Dooley Davina Ghersi David Moher Mark Petticrew Lesley Stewart - of PROSPERO: an
Following publication of the PRISMA statement, the UK Centre for Reviews and Dissemination (CRD) at the University of York in England began to develop an international prospective register of systematic reviews with health-related outcomes. The objectives were to reduce unplanned duplication of reviews and provide transparency in the review process, with the aim of minimizing...
In a systematic review of cohort studies, Kerry Dwan and colleagues examine the evidence for selective reporting and discrepancies in analyses between journal publications and other documents for clinical trials. Please see later in the article for the Editors' Summary
colloquia. Mike Clarke is employed as Director of the UK Cochrane Centre and to work on systematic reviews.This employment depends on the value placed on the work of the Cochrane Collaboration and systematic ... Christian Medical College in Vellore,Tamil Nadu, India, and Coordinator of the South Asian Cochrane Network. Mike Clarke is Director of the UK Cochrane Centre in Oxford, United Kingdom. Sally Green is
Siegfried is a South African Nuffield Medical Fellow at the University of Oxford (Oxford, United Kingdom). Mike Clarke is Director of the United Kingdom Cochrane Centre (Oxford, United Kingdom).The authors ... are involved in the work of the Cochrane Collaboration, but the views expressed in this article are their own and are not necessarily those of the Cochrane Collaboration 1 , Nandi Siegfried , Mike
Martin Gerdin and colleagues argue that disaster health interventions and decision-making can benefit from an evidence-based approach Please see later in the article for the Editors' Summary
