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Inverse association of marijuana use with nonalcoholic fatty liver disease among adults in the United States

Ahmed. Investigation: Donghee Kim, Aijaz Ahmed. Data curation: Donghee Kim, Won Kim, Min-Sun Kwak, Goh Eun Chung, Jeong Yoon Yim. Methodology: Donghee Kim, Won Kim, Min-Sun Kwak, Goh Eun Chung, Jeong ... Yoon Yim. Resources: Won Kim, Min-Sun Kwak, Goh Eun Chung, Jeong Yoon Yim. Supervision: Aijaz Ahmed. Writing ± original draft: Donghee Kim. Writing ± review & editing: Donghee Kim, Won Kim, Min-Sun

Identification of two mutation sites in spike and envelope proteins mediating optimal cellular infection of porcine epidemic diarrhea virus from different pathways

Entry of the α-coronavirus porcine epidemic diarrhea virus (PEDV) requires specific proteases to activate spike (S) protein for the membrane fusion of the virion to the host cell following receptor binding. Herein, PEDV isolate 85-7 could proliferate and induce cell–cell fusion in a trypsin independent manner on Vero cells, and eight homologous mutation strains were screened by ...

Quantitative analysis of retinal layers on three-dimensional spectral-domain optical coherence tomography for pituitary adenoma

Purpose To quantitatively investigate the characteristics of eyes with pituitary adenoma presented by three-dimensional (3D) spectral-domain optical coherence tomography (SD-OCT) using three common indices, including thickness, optical intensity ratio, and optical intensity attenuation coefficient (OIAC). Methods The SD-OCT database of 38 patients with pituitary adenoma and 39 ...

Phase-specific expression of an insulin-like androgenic gland factor in a marine shrimp Lysmata wurdemanni: Implication for maintaining protandric simultaneous hermaphroditism

Background Shrimp in the genus Lysmata have a unique and rare sexual system referred to as protandric simultaneous hermaphroditism, whereby individuals mature first as male (male phase), and then the female function may also develop as the shrimp grow, so that the gonad is able to produce both eggs and sperms simultaneously, a condition called simultaneous hermaphroditism ...

The prevalence and clinical manifestation of hereditary thrombophilia in Korean patients with unprovoked venous thromboembolisms

Kim, Duk-Kyung Kim. Data curation: Su Yeon Lee, Min Sun Kim, Sun Hye Shin, Haseong Chang, Shin Yi Jang. Formal analysis: Su Yeon Lee, Eun Kyoug Kim, Min Sun Kim, Sun Hye Shin, Haseong Chang, Duk-Kyung

Efficacy and safety of micafungin versus extensive azoles in the prevention and treatment of invasive fungal infections for neutropenia patients with hematological malignancies: A meta-analysis of randomized controlled trials

curation: Cho-Hao Lee, Min Sun, Wel-Ting Yen, Chin Lin. Formal analysis: Cho-Hao Lee, Min Sun, Chin Lin. Investigation: Cho-Hao Lee, Wel-Ting Yen, Chin Lin. Methodology: Cho-Hao Lee, Chin Lin. Project

An inexact generalized PRSM with LQP regularization for structured variational inequalities and its applications to traffic equilibrium problems

Min Sun 1 Jing Liu 0 0 School of Data Sciences, Zhejiang University of Finance and Economics , Hangzhou, 310018 , China 1 School of Mathematics and Statistics, Zaozhuang University , Zaozhuang, Shandong

Emergence of rifampin-resistant staphylococci after rifaximin administration in cirrhotic patients

individual has been removed. (XLSX) Author Contributions Conceptualization: Seong-Eun Kim. Data curation: Ji Young Chang, Min Sun Ryu, Yang-Hee Joo, Ko Eun Lee, Jihyun Lee, Kang Hoon Lee. Formal analysis

Diagnostic performance of confocal laser endomicroscopy for optical diagnosis of gastric intestinal metaplasia: a meta-analysis

Background Gastric intestinal metaplasia (IM) is generally considered as a precancerous condition, a related risk factor for intestinal-type gastric cancer. However, an accurate endoscopic diagnosis of IM is a clinical challenge. Confocal Laser Endomicroscopy (CLE) is a newly technique that can provide real-time magnified images and visualize tissues at cellular or subcellular ...

Molecular Dynamics Simulations of the Human Glucose Transporter GLUT1

Glucose transporters (GLUTs) provide a pathway for glucose transport across membranes. Human GLUTs are implicated in devastating diseases such as heart disease, hyper- and hypo-glycemia, type 2 diabetes and caner. The human GLUT1 has been recently crystalized in the inward-facing open conformation. However, there is no other structural information for other conformations. The X-ray ...

Three modified Polak-Ribière-Polyak conjugate gradient methods with sufficient descent property

In this paper, three modified Polak-Ribière-Polyak (PRP) conjugate gradient methods for unconstrained optimization are proposed. They are based on the two-term PRP method proposed by Cheng (Numer. Funct. Anal. Optim. 28:1217-1230, 2007), the three-term PRP method proposed by Zhang et al. (IMA J. Numer. Anal. 26:629-640, 2006), and the descent PRP method proposed by Yu et al. ...

Event-specific detection of transgenic potato AV43-6-G7 using real-time and digital PCR methods

Background The isolation of unknown DNA sequences flanked by known sequences is an important task in the event-specific detection of GMOs. None of event-specific detection method was developed based on the junction sequence of an exogenous integrant in the transgenic potato AV43-6-G7. Results The flanking sequence between the exogenous fragment and recombinant chromosome of this ...

Purification and characterization of a novel ginsenoside Rc-hydrolyzing β-glucosidase from Armillaria mellea mycelia

Ginsenosides are the principal compounds responsible for the pharmacological effects and health benefits of Panax ginseng root. Among protopanaxadiol (PPD)-type ginsenosides, minor ginsenosides such as ginsenoside (G)-F2, G-Rh2, compound (C)-Mc1, C-Mc, C-O, C-Y, and C-K are known to be more pharmacologically active constituents than major ginsenosides such as G-Rb1, G-Rb2, G-Rc, ...

Dynamic Contrast-Enhanced MRI Perfusion Parameters as Imaging Biomarkers of Angiogenesis

Hypoxia in the tumor microenvironment is the leading factor in angiogenesis. Angiogenesis can be identified by dynamic contrast-enhanced breast MRI (DCE MRI). Here we investigate the relationship between perfusion parameters on DCE MRI and angiogenic and prognostic factors in patients with invasive ductal carcinoma (IDC). Perfusion parameters (Ktrans, kep and ve) of 81 IDC were ...

Variation of Bacterial Community Diversity in Rhizosphere Soil of Sole-Cropped versus Intercropped Wheat Field after Harvest

As the major crops in north China, spring crops are usually planted from April through May every spring and harvested in fall. Wheat is also a very common crop traditionally planted in fall or spring and harvested in summer year by year. This continuous cropping system exhibited the disadvantages of reducing the fertility of soil through decreasing microbial diversity. Thus, ...

Electroacupuncture Produces the Sustained Motor Improvement in 6-Hydroxydopamine-Lesioned Mice

Clinical and research evidence has shown that electroacupuncture (EA) promotes recovery of motor function in patients with Parkinson’s disease (PD). However, the “efficacy span” of EA treatment, especially the long-term effect of EA that is thought to last after the cessation of EA treatment, has not been investigated. The present study thus investigated and compared the effect of ...

Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potential therapeutic target

This study investigated the significance of La-related protein 1 (LARP1) in the development and progression of colorectal cancer (CRC). Quantitative real-time polymerase chain reaction and Western blot analyses were carried out to determine the mRNA and protein expression of LARP1 in CRC tumor tissues and paired adjacent normal mucosa. The expression of LARP1 was upregulated in ...

Small Bowel Stromal Tumors: Different Clinicopathologic and Computed Tomography Features in Various Anatomic Sites

Gastrointestinal stromal tumors (GISTs) can present with different clinical and immunohistochemical characteristics according to different anatomic sites. The aim of this study was to compare clinicopathologic and computed tomography (CT) features of small bowel stromal tumors located in the duodenum, jejunum, and ileum. In total, 197 patients (109 male, 88 female) with small bowel ...