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128 papers found.
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Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells

Chen, Min Xu, Joseph A. Garcia. Formal analysis: Rui Chen, Min Xu, Jason Nagati, Joseph A. Garcia. Funding acquisition: Joseph A. Garcia. Investigation: Rui Chen, Min Xu, Jason Nagati, Joseph A

Investigation of the deterioration of passive films in H2S-containing solutions

The effect of H2S on the corrosion behavior of 316L stainless steel was investigated using electrochemical methods by changing the gas condition from CO2 to H2S and then back to CO2. The presence of H2S showed an acceleration effect on the corrosion of 316L stainless steel in comparison with CO2. The acceleration effect remained even after the complete removal of H2S by CO2, ...

Effect of intravenous immunoglobulin on the function of Treg cells derived from immunosuppressed mice with Pseudomonas aeruginosa pneumonia

Aim The present study aimed to investigate the effect of intravenous immunoglobulin (IVIG) on regulatory T (Treg) cells derived from immunosuppressed mice with Pseudomonas aeruginosa (PA) pneumonia. Methods A total of 108 BALB/c mice were randomly divided into the following groups: control group (Control), immunosuppressed group (IS), PA pneumonia group (PA), PA pneumonia in ...

Simulating cryo electron tomograms of crowded cell cytoplasm for assessment of automated particle picking

Background Cryo-electron tomography is an important tool to study structures of macromolecular complexes in close to native states. A whole cell cryo electron tomogram contains structural information of all its macromolecular complexes. However, extracting this information remains challenging, and relies on sophisticated image processing, in particular for template-free particle ...

Attachment strength of the subtidal seaweed Sargassum horneri (Turner) C. Agardh varies among development stages and depths

Sargassum horneri is one of the most important contributors to the rafts of floating seaweed in the waters off the coasts of northeastern Asia. These rafts serve as spawning and nursery grounds for many marine organisms, including Japanese saury and yellowtail. Thus, the details of the attachment/detachment mechanisms of S. horneri are of commercial significance for the aquaculture ...

Solid oxide fuel cell interconnect design optimization considering the thermal stresses

The mechanical failure of solid oxide fuel cell (SOFC) components may cause cracks with consequences such as gas leakage, structure instability and reduction of cell lifetime. A comprehensive 3D model of the thermal stresses of an anode-supported planar SOFC is presented in this work. The main objective of this paper is to get an interconnect optimized design by evaluating the ...

Characteristic changes in aerosol and meteorological parameters associated with dust event of 9 March 2013

Dust storms are very common in China during spring (March–May) season. On 8–9 March 2013, an intense dust storm occurred, which affected north-eastern parts of China including capital city Beijing. Satellite data are very important in tracking dust events; satellite and ground observations provide very important information about the transport of dust, their optical, atmospheric ...

Over-expression of the long non-coding RNA HOTTIP inhibits glioma cell growth by BRE

Background Gliomas are the most common type of primary brain tumour in the central nervous system of adults. The long non-coding RNA (lncRNA) HOXA transcript at the distal tip (HOTTIP) is transcribed from the 5′ tip of the HOXA locus. HOTTIP has recently been shown to be dysregulated and play an important role in the progression of several cancers. However, little is known about ...

Thyroid hormones associate with risk of incident chronic kidney disease and rapid decline in renal function: a prospective investigation

Background Thyroid hormones have been associated with renal dysfunction in cross-sectional studies. However, prospective studies exploring the effect of thyroid hormones on renal function decline were sparse and got contradictive results. We aimed to prospectively explore the associations of thyroid hormones with incident chronic kidney disease (CKD) and rapid decline in estimated ...

Thyroid hormones associate with risk of incident chronic kidney disease and rapid decline in renal function: a prospective investigation

Background Thyroid hormones have been associated with renal dysfunction in cross-sectional studies. However, prospective studies exploring the effect of thyroid hormones on renal function decline were sparse and got contradictive results. We aimed to prospectively explore the associations of thyroid hormones with incident chronic kidney disease (CKD) and rapid decline in estimated ...

Structural insights into the regulatory mechanism of the Pseudomonas aeruginosa YfiBNR system

formation - Min Xu, Xuan Yang and Xiu-An Yang have contributed equally to this work. INTRODUCTION Bis-(3’-5’)-cyclic dimeric GMP (c-di-GMP) is a ubiquitous second messenger that bacteria use to facilitate ... -associated lipoprotein; PDEs, phosphodiesterases; PG, peptidoglycan; VB6, Vitamin B6 COMPLIANCE WITH ETHICS GUIDELINES Min Xu, Xuan Yang, Xiu-An Yang, Lei Zhou, Tie-Zheng Liu, Zusen Fan and Tao Jiang declare

Linc-RoR promotes c-Myc expression through hnRNP I and AUF1

Xu 7 Yin-Yuan Mo 2 6 0 Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine , Chicago, IL , USA 1 Department of Biochemistry, University of Mississippi Medical Center

Lung-specific RNA interference of coupling factor 6, a novel peptide, attenuates pulmonary arterial hypertension in rats

Background Pulmonary arterial hypertension (PAH) is a progressive and life-threatening disease associated with high morbidity and mortality rates. However, the exact regulatory mechanism of PAH is unknown. Although coupling factor 6 (CF6) is known to function as a repressor, its role in PAH has not been explored. Here, we investigated the involvement of endogenous CF6 in the ...

Automated target segmentation and real space fast alignment methods for high-throughput classification and averaging of crowded cryo-electron subtomograms

Motivation: Cryo-electron tomography allows the imaging of macromolecular complexes in near living conditions. To enhance the nominal resolution of a structure it is necessary to align and average individual subtomograms each containing identical complexes. However, if the sample of complexes is heterogeneous, it is necessary to first classify subtomograms into groups of identical ...

Genetic Variants of BMP2 and Their Association with the Risk of Non-Syndromic Tooth Agenesis

Non-syndromic tooth agenesis (or non-syndromic congenitally missing tooth) is one of the most common congenital defects in humans affecting the craniofacial function and appearance. Single nucleotide polymorphisms (SNPs) have been associated with an individual’s susceptibility to these anomalies. The aim of the present study was therefore to investigate the roles of the potentially ...

Interaction of ApoA-IV with NR4A1 and NR1D1 Represses G6Pase and PEPCK Transcription: Nuclear Receptor-Mediated Downregulation of Hepatic Gluconeogenesis in Mice and a Human Hepatocyte Cell Line

We have previously shown that the nuclear receptor, NR1D1, is a cofactor in ApoA-IV-mediated downregulation of gluconeogenesis. Nuclear receptor, NR4A1, is involved in the transcriptional regulation of various genes involved in inflammation, apoptosis, and glucose metabolism. We investigated whether NR4A1 influences the effect of ApoA-IV on hepatic glucose metabolism. Our in situ ...

Consumption of whole grains and cereal fiber and total and cause-specific mortality: prospective analysis of 367,442 individuals

Background Intakes of whole grains and cereal fiber have been inversely associated with the risk of chronic diseases; however, their relation with total and disease-specific mortality remain unclear. We aimed to prospectively assess the association of whole grains and cereal fiber intake with all causes and cause-specific mortality. Methods The study included 367,442 participants ...

TNF-alpha and IL-6 inhibit apolipoprotein A-IV production induced by linoleic acid in human intestinal Caco2 cells

Background Apolipoprotein A-IV (apoA-IV) is a protein mainly synthesized by enterocytes in the intestine. Its gene expression is suppressed during fasting and stimulated during active fat absorption. Chronic feeding of a high-fat (HF) diet abolishes the differential expression between fasting and fat-feeding and therefore may contribute to diet-induced obesity since apoA-IV is a ...