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Food web properties of the recently constructed, deep subtropical Fei-Tsui Reservoir in comparison with the ancient Lake Biwa

Using carbon and nitrogen stable isotope analysis, we characterised food web properties of the deep subtropical Fei-Tsui Reservoir (FTR), which was recently altered from a lotic to a lentic system after dam construction. In the littoral zone, zoobenthos showed strong reliance (83.9%) on benthic algal production. Zoobenthos were never found in the profundal zone because of anoxia. ...

Risk of cardiovascular disease in Chinese patients with rheumatoid arthritis: A cross-sectional study based on hospital medical records in 10 years

Objective Though the risk of cardiovascular disease (CVD) in rheumatoid arthritis (RA) has been established in Western population, little is known about the risk in Chinese people with RA. Our objective was to estimate the risk of CVD in Chinese people with RA using hospital medical records data. Methods The inpatients medical record database 2005–2015 of Sichuan provincial ...

Deformation behaviors of peat with influence of organic matter

Peat is a kind of special material rich in organic matter. Because of the high content of organic matter, it shows different deformation behaviors from conventional geotechnical materials. Peat grain has a non-negligible compressibility due to the presence of organic matter. Biogas can generate from peat and can be trapped in form of gas bubbles. Considering the natural properties ...

Enhancement of pomalidomide anti-tumor response with ACY-241, a selective HDAC6 inhibitor

Thalidomide-based Immunomodulatory Drugs (IMiDs®), including lenalidomide and pomalidomide, are effective therapeutics for multiple myeloma. These agents have been approved with, or are under clinical development with, other targeted therapies including proteasome inhibitors, αCD38 monoclonal antibodies, as well as histone deacetylase (HDAC) inhibitors for combination therapy. HDAC ...

Leptonic mono-top from single stop production at the LHC

Top squark (stop) can be produced via QCD interaction but also the electroweak interaction at the LHC. In this paper, we investigate the observability of the associated production of stop and chargino, \( pp\to {\tilde{t}}_1{\tilde{\chi}}_{\overline{1}} \), in compressed electroweakino scenarios at 14 TeV LHC. Due to small mass splitting between the lightest neutralino (\( ...

Top-squark in natural SUSY under current LHC run-2 data

We utilize the recent LHC-13 TeV data to study the lower mass bound on the top-squark (stop) in natural supersymmetry. We recast the LHC sparticle inclusive search of 1) with \(\alpha _T\) variable, the direct stop pair search (1-lepton channel and all-hadronic channel) and the monojet analyses. We find that these searches are complementary depending on stop and higgsino masses: ...

Effect of active vitamin D3 on VEGF-induced ADAM33 expression and proliferation in human airway smooth muscle cells: implications for asthma treatment

Background Asthma is a chronic respiratory disease characterized by reversible airway obstruction with persistent airway inflammation and airway remodeling, which is associated with increased airway smooth muscle (ASM) mass. Vascular endothelial growth factor (VEGF) has been implicated in inflammatory and airway blood vessel remodeling in asthma. Recent evidence indicates that a ...

Radiative natural SUSY spectrum from deflected AMSB scenario with messenger-matter interactions

A radiative natural SUSY spectrum are proposed in the deflected anomaly mediation scenario with general messenger-matter interactions. Due to the contributions from the new interactions, positive slepton masses as well as a large |A t | term can naturally be obtained with either sign of deflection parameter and few messenger species (thus avoid the possible Landau pole problem). In ...

Macrophage phenotypic subtypes diametrically regulate epithelial-mesenchymal plasticity in breast cancer cells

Background Metastatic progression of breast cancer involves phenotypic plasticity of the carcinoma cells moving between epithelial and mesenchymal behaviors. During metastatic seeding and dormancy, even highly aggressive carcinoma cells take on an E-cadherin-positive epithelial phenotype that is absent from the emergent, lethal metastatic outgrowths. These phenotypes are linked to ...

A GCM with cloud microphysics and its MJO simulation

The present study examines the Madden and Julian oscillation (MJO) appearing in a general circulation model (GCM) with full representation of cloud microphysics at 50 km horizontal resolution, and the MJO is compared with those of GCMs with conventional convective parameterizations. The present coarse-resolution GCM requires modifications of several parameters of cloud microphysics ...

A GntR family transcription factor positively regulates mycobacterial isoniazid resistance by controlling the expression of a putative permease

Yang 0 0 College of Life Science and Technology, Huazhong Agricultural University , Wuhan 430070 , China 1 National Key Laboratory of Agricultural Microbiology, Center for Proteomics Research, College

Consecutive Short-Scan CT for Geological Structure Analog Models with Large Size on In-Situ Stage

For the analysis of interior geometry and property changes of a large-sized analog model during a loading or other medium (water or oil) injection process with a non-destructive way, a consecutive X-ray computed tomography (XCT) short-scan method is developed to realize an in-situ tomography imaging. With this method, the X-ray tube and detector rotate 270° around the center of the ...

Selective Inhibitors of Histone Deacetylases 1 and 2 Synergize with Azacitidine in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic stem cell disorders characterized by defects in myeloid differentiation and increased proliferation of neoplastic hematopoietic precursor cells. Outcomes for patients with AML remain poor, highlighting the need for novel treatment options. Aberrant epigenetic regulation plays an important role in the ...

Effect of microbial transglutaminase crosslinking on the functional properties of yak caseins: a comparison with cow caseins

Microbial transglutaminase (mTGase) crosslinking is a useful method for significantly improving the physical functionality of proteins. This study focused on the effect of mTGase modification on the functional properties of yak and cow caseins, including solubility, emulsifying property, water and oil absorption capacity, foaming property, and stability in the presence of Na+, ...

Reconcile muon g-2 anomaly with LHC data in SUGRA with generalized gravity mediation

From generalized gravity mediation we build a SUGRA scenario in which the gluino is much heavier than the electroweak gauginos at the GUT scale. We find that such a non-universal gaugino scenario with very heavy gluino at the GUT scale can be naturally obtained with proper high dimensional operators in the framework of SU(5) GUT. Then, due to the effects of heavy gluino, at the ...

The maximal \(U(1)_L\) inverse seesaw from \(d=5\) operator and oscillating asymmetric Sneutrino dark matter

The maximal \(U(1)_L\) supersymmetric inverse seesaw mechanism (MLSIS) provides a natural way to relate asymmetric dark matter (ADM) with neutrino physics. In this paper we point out that MLSIS is a natural outcome if one dynamically realizes the inverse seesaw mechanism in the next-to minimal supersymmetric standard model (NMSSM) via the dimension-five operator \((N)^2S^2/M_*\), ...

Proteasome Inhibition Contributed to the Cytotoxicity of Arenobufagin after Its Binding with Na, K-ATPase in Human Cervical Carcinoma HeLa Cells

Although the possibility of developing cardiac steroids/cardiac glycosides as novel cancer therapeutic agents has been recognized, the mechanism of their anticancer activity is still not clear enough. Toad venom extract containing bufadienolides, which belong to cardiac steroids, has actually long been used as traditional Chinese medicine in clinic for cancer therapy in China. The ...

Explanation of the ATLAS Z-peaked excess by squark pair production in the NMSSM

The ATLAS collaboration recently reported a 3σ excess in the leptonic-Z + jets + E T miss channel. We intend to interpret this excess by squark pair production in the Next-to-Minimal Supersymmetric Standard Model (NMSSM). The decay chain we employ is \( \tilde{q}\to q{\tilde{\chi}}_2^0\to q{\tilde{\chi}}_1^0Z \), where \( {\tilde{\chi}}_1^0 \) and \( {\tilde{\chi}}_2^0 \) denote ...

A split SUSY model from SUSY GUT

We propose to split the sparticle spectrum from the hierarchy between the GUT scale and the Planck scale. A split supersymmetric model, which gives non-universal gaugino masses, is built with proper high dimensional operators in the framework of SO(10) GUT. Based on a calculation of two-loop beta functions for gauge couplings (taking into account all weak scale threshold ...