Mild cognitive impairment (MCI) associated with diabetes mellitus (DM) is common among older adults, and self-management is critical to controlling disease progression. However, both MCI and DM are heterogeneous diseases, and existing integrated self-management interventions do not consider patient differences. Grouping patients by disease characteristics could help to...
The molecular mechanisms contributing to the regulation of Th17-mediated inflammation remain underexplored. We here report a SUMO-specific protease (SENP)2-mediated pathway induced in pathogenic Th17 cells that restricts the pathogenesis of inflammatory colitis. SENP2 regulates the maturation of small ubiquitin-like modifiers (SUMO) and recycles SUMO from the substrate proteins...
With growing environmental concerns and the exploitation of ubiquitous big data, smart transportation is transforming logistics business and operations into a more sustainable approach. To answer questions in intelligent transportation planning, such as which data are feasible, which methods are applicable for intelligent prediction of such data, and what are the available...
the original manuscript. Chun‑ Wei Chang acquired the data. Chia‑ Yin Chien, Chun‑ Wei Chang, Ming‑Feng Liao and Hung‑ Chou Kuo conceived the study. Hung‑ Chou Kuo and Chun‑ Wei Chang revised the
Mulberry Diels–Alder-type adducts (MDAAs) are unique phenolic natural products biosynthetically derived from the intermolecular [4 + 2]-cycloaddition of dienophiles (mainly chalcones) and dehydroprenylphenol dienes, which are exclusively distributed in moraceous plants. A total of 166 MDAAs with diverse skeletons have been isolated and identified since 1980. Structurally, the...
The era of big data brings opportunities and challenges to developing new statistical methods and models to evaluate social programs or economic policies or interventions. This paper provides a comprehensive review on some recent advances in statistical methodologies and models to evaluate programs with high-dimensional data. In particular, four kinds of methods for making valid...
Isaacs’ syndrome is a peripheral nerve hyperexcitability (PNH) syndrome due to peripheral motor nerve instability. Acquired Isaacs’ syndrome is recognized as a paraneoplastic autoimmune disease with possible pathogenic voltage-gated potassium channel (VGKC) complex antibodies. However, the longitudinal correlation between clinical symptoms, VGKC antibodies level, and drug...
Reprogramming of metabolism is strongly associated with the development of cancer. However, the role of metabolic reprogramming in the remodeling of pre-metastatic niche (PMN), a key step in metastasis, is still unknown. We aimed to investigate the metabolic alternation during lung PMN formation in breast cancer. We assessed the transcriptomes and lipidomics of lung of MMTV-PyVT...
The trend of women suffering from early-onset breast cancer is increasing in Taiwan. The association of early-onset breast cancer with body mass index (BMI), menarche, and menopausal status has focused interest on the field of cancer epidemiology; however, few studies have explored the interaction of these factors on early-onset risk. This study aimed to estimate the interaction...
Jeng‑Guan Hsu 3 Ming‑Feng Chiang 4 Tian‑Shyug Lee 3 SzuY‑u 0 Division of Radiation Oncology, Lo‐Hsu Medical Foundation, Lotung Poh‐Ai Hospital , No. 83, Nanchang St., Luodong Township, Yilan County 265
The tumor microenvironment represents one of the main obstacles in breast cancer treatment owing to the presence of heterogeneous stromal cells, such as adipose-derived stem cells (ADSCs), that may interact with breast cancer cells and promote cancer development. Resistin is an adipocytokine associated with adverse breast cancer progression; however, its underlying mechanisms in...
Global warming is the main cause for the rise of both global temperatures and sea-level, both major variables threatening biodiversity. Rising temperatures threaten to breach the thermal limits of organisms while rising sea-level threatens the osmotic balance of coastal animals through habitat salinization. However, variations in thermal tolerance under different salinity...
The association between phthalate exposure and breast cancer remains controversial. We performed a prospective patient cohort design to explore the interaction between creatinine-corrected urinary phthalate metabolites and hormone receptors as well as body mass index (BMI) on recurrent breast cancer. In this follow-up study, 636 female breast cancer patients and 45 new recurrent...
standards Conflict of interest Shi-Ming Feng, Nicola Maffulli, Chao Ma and Francesco Oliva declare that they have no conflict of interest. None of the authors have any conflict of interest regarding this
, Hsinchu, 30013, Taiwan Ming-Feng Hsieh, Chin Lung Lu & Chuan Yi Tang Department of Computer Science and Information Engineering, Providence University, Taichung, 43301, Taiwan Chuan Yi Tang AuthorsMing
Research Article | Open Access Volume 2021 |Article ID 6593015 | https://doi.org/10.1155/2021/6593015 Peng Su, Jinqiang Gan, Teng-Fei Ding, Chang-Duo Liang, Ming-Feng Ge, "Practical
Recent research shows that 90% of the net global ocean heat gain during 2005–2015 was confined to the southern hemisphere with little corresponding heat gain in the northern hemisphere ocean. We propose that this heating pattern of the ocean is driven by anthropogenic climate change and an asymmetric climate variation between the two hemispheres. This asymmetric variation is...
, Designed and conceptualized the study, analyzed the data, drafted the manuscript for intellectual content; Ming-Feng Liao, MD, Major role in the acquisition of data; Kuo-Hsuan Chang, MD, PhD, Major role in
The electrochemical production of green and low-cost ammonia requests the development of high-performance electrocatalysts. In this work, the ampoule method was applied to modulate the surface of the zinc electrode by implanting defects and low-valent active sites. The N-doped ZnS electrocatalyst was thus generated by sulfurization with thiourea and applied for electrocatalytic...
, Tsung-Yu Tsai, Chieh-Yu Pan. Funding acquisition: Jyh-Yih Chen. Investigation: Ming-Feng You, Chia-Hua Lin. Methodology: Ming-Feng You. Supervision: Chieh-Yu Pan, Jyh-Yih Chen. Validation: Chieh-Yu