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11 papers found.
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Influenza A H5N1 and H7N9 in China: A spatial risk analysis

Background Zoonotic avian influenza poses a major risk to China, and other parts of the world. H5N1 has remained endemic in China and globally for nearly two decades, and in 2013, a novel zoonotic influenza A subtype H7N9 emerged in China. This study aimed to improve upon our current understanding of the spreading mechanisms of H7N9 and H5N1 by generating spatial risk profiles...

Causal effect of smoking on DNA methylation in peripheral blood: a twin and family study

BackgroundSmoking has been reported to be associated with peripheral blood DNA methylation, but the causal aspects of the association have rarely been investigated. We aimed to investigate the association and underlying causation between smoking and blood methylation.MethodsThe methylation profile of DNA from the peripheral blood, collected as dried blood spots stored on Guthrie...

Intragenic DNA methylation in buccal epithelial cells and intellectual functioning in a paediatric cohort of males with fragile X

• Google Scholar Search for Lesley Bretherton in:Nature Research journals • PubMed • Google Scholar Search for Minh Bui in:Nature Research journals • PubMed • Google Scholar Search for Xin Li in:Nature

CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells

for the gift of recombinant histones; Dr. Sam John for expert advice on DHS assays; Drs. Andre Nussenzweig, Tom Misteli, Minh Bui, and Delphine Quenet for critical comments on the manuscript; Tatiana

Taxon Selection under Split Diversity

The “phylogenetic diversity” (PD) measure of biodiversity is evaluated using a phylogenetic tree, usually inferred from morphological or molecular data. Consequently, it is vulnerable to errors in that tree, including those resulting from sampling error, model misspecification, or conflicting signals. To improve the robustness of PD, we can evaluate the measure using either a...

MicroRNA Related Polymorphisms and Breast Cancer Risk

Genetic variations, such as single nucleotide polymorphisms (SNPs) in microRNAs (miRNA) or in the miRNA binding sites may affect the miRNA dependent gene expression regulation, which has been implicated in various cancers, including breast cancer, and may alter individual susceptibility to cancer. We investigated associations between miRNA related SNPs and breast cancer risk...