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Chronic restraint stress induces excessive activation of primordial follicles in mice ovaries

: Minhua Xu, Junyan Sun, Qiuwan Zhang. Methodology: Minhua Xu, Junyan Sun, Qian Wang, Qiuwan Zhang. Project administration: Minhua Xu, Junyan Sun, Qian Wang, Chunsheng Wei, Dongmei Lai. Resources: Dongmei ... Lai. Supervision: Chunsheng Wei, Dongmei Lai. Writing ± original draft: Minhua Xu. Writing ± review & editing: Chunsheng Wei, Dongmei Lai. 14 / 17 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22

Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage

Background Human amniotic epithelial cells (hAECs) are attractive candidates for regenerative medical therapy, with the potential to replace deficient cells and improve functional recovery after injury. Previous studies have demonstrated that transplantation of hAECs effectively alleviate chemotherapy-induced ovarian damage via inhibiting granulose cells apoptosis in animal...

Human amniotic epithelial cells inhibit granulosa cell apoptosis induced by chemotherapy and restore the fertility

Introduction Premature ovarian failure and insufficiency are significant long-term side-effects of chemotherapy for female cancer patients. Recently, stem cell transplantation has been identified as a promising treatment for premature ovarian failure and insufficiency. We have previously demonstrated that human amniotic epithelial cells (hAECs) migrate into injured tissue and...

Restoring the Secretory Function of Irradiation-Damaged Salivary Gland by Administrating Deferoxamine in Mice

Objectives One of the major side effects of radiotherapy for treatments of the head and neck cancer is the radiation-induced dysfunction of salivary glands. The aim of the present study is to investigate the efficacy of deferoxamine (DFO) to restore the secretory function of radiation-damaged salivary glands in mice. Methods DFO (50 mg/kg/d) was administered intraperitoneally in...

Identification and characterization of epithelial cells derived from human ovarian follicular fluid

Introduction Follicular fluid is important for follicular development and oocyte maturation. Evidence suggests that follicular fluid is not only rich in proteins but cells. Besides oocytes, the follicular fluid contains granulosa, thecal, and ovarian surface epithelial cells, and both granulosa and thecal cells are well-characterized. However, epithelial cells in follicular fluid...