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Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection

Purpose. To examine the difference in the vitreal protein profiles of patients with proliferative diabetic retinopathy (PDR) with and without preoperative intravitreal conbercept (IVC) treatment. Methods. Liquid chromatography-tandem mass spectrometry- (LC-MS/MS-) based proteomic methods were used to determine the protein profiles of the vitreous humor in patients with PDR...

Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection

Purpose. To examine the difference in the vitreal protein profiles of patients with proliferative diabetic retinopathy (PDR) with and without preoperative intravitreal conbercept (IVC) treatment. Methods. Liquid chromatography-tandem mass spectrometry- (LC-MS/MS-) based proteomic methods were used to determine the protein profiles of the vitreous humor in patients with PDR...

Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection

Purpose. To examine the difference in the vitreal protein profiles of patients with proliferative diabetic retinopathy (PDR) with and without preoperative intravitreal conbercept (IVC) treatment. Methods. Liquid chromatography-tandem mass spectrometry- (LC-MS/MS-) based proteomic methods were used to determine the protein profiles of the vitreous humor in patients with PDR...

Change of ranibizumab-induced human vitreous protein profile in patients with proliferative diabetic retinopathy based on proteomics analysis

Preoperative treatment of anti-vascular endothelial growth factor (VEGF) agents is extensively used in proliferative diabetic retinopathy (PDR), but the molecular mechanism is not fully understood. The objective of this research is to observe change of protein profile induced by ranibizumab (an anti-VEGF agent) in vitreous humor from PDR patients and reveal the effects of anti...

Diabetes Onset at 31–45 Years of Age is Associated with an Increased Risk of Diabetic Retinopathy in Type 2 Diabetes

. AffiliationsDepartment of Ophthalmology, Shanghai First People’s Hospital of Nanjing Medical University, Shanghai 200080, ChinaWenjun Zou, Minjie Zhao & Zhi ZhengDepartment of Ophthalmology, Nanjing Medical University ... for Chen Zou in:Nature Research journals • PubMed • Google ScholarSearch for Minjie Zhao in:Nature Research journals • PubMed • Google ScholarSearch for Xun Xu in:Nature Research journals • PubMed

Immobilization, Regiospecificity Characterization and Application of Aspergillus oryzae Lipase in the Enzymatic Synthesis of the Structured Lipid 1,3-Dioleoyl-2-Palmitoylglycerol

The enzymatic synthesis of 1,3-dioleoyl-2-palmitoylglycerol (OPO), one of the main components of human milk fats, has been hindered by the relatively high cost of sn-1,3-specific lipases and the deficiency in biocatalyst stability. The sn-1,3-specific lipase from Aspergillus oryzae (AOL) is highly and efficiently immobilized with the polystyrene-based hydrophobic resin D3520...

Simultaneous Determination of Various Isothiocyanates by RP-LC Following Precolumn Derivatization with Mercaptoethanol

Numerous isothiocyanates (ITCs) are poorly soluble in water which causes their precipitation in aqueous mobile phases used in reversed phase liquid chromatography (RP-LC), thus impacting the accuracy of the quantification. By comparing the amounts of ITCs injected and released from the column, losses could be estimated at 5–32% depending on polarities and concentrations. Results...

Oxidative Stress Type Influences the Properties of Antioxidants Containing Polyphenols in RINm5F Beta Cells

 Christian Muller,2 Minjie Zhao,3 Eric Marchioni,3 Michel Pinget,1,4,5 Nathalie Jeandidier,1,4,5 Elisa Maillard,1 Valérie Schini-Kerth,5 and Séverine Sigrist1 1UMR DIATHEC, EA 7294, Centre Européen d’Etude du

Oxidative Stress Type Influences the Properties of Antioxidants Containing Polyphenols in RINm5F Beta Cells

 Christian Muller,2 Minjie Zhao,3 Eric Marchioni,3 Michel Pinget,1,4,5 Nathalie Jeandidier,1,4,5 Elisa Maillard,1 Valérie Schini-Kerth,5 and Séverine Sigrist1 1UMR DIATHEC, EA 7294, Centre Européen d’Etude du

Oxidative Stress Type Influences the Properties of Antioxidants Containing Polyphenols in RINm5F Beta Cells

 Christian Muller,2 Minjie Zhao,3 Eric Marchioni,3 Michel Pinget,1,4,5 Nathalie Jeandidier,1,4,5 Elisa Maillard,1 Valérie Schini-Kerth,5 and Séverine Sigrist1 1UMR DIATHEC, EA 7294, Centre Européen d’Etude du

Oxidative Stress Type Influences the Properties of Antioxidants Containing Polyphenols in RINm5F Beta Cells

 Christian Muller,2 Minjie Zhao,3 Eric Marchioni,3 Michel Pinget,1,4,5 Nathalie Jeandidier,1,4,5 Elisa Maillard,1 Valérie Schini-Kerth,5 and Séverine Sigrist1 1UMR DIATHEC, EA 7294, Centre Européen d’Etude du

Icacina senegalensis (Icacinaceae), traditionally used for the treatment of malaria, inhibits in vitro Plasmodium falciparum growth without host cell toxicity

Serigne O Sarr Sylvie Perrotey Ibrahima Fall Sad Ennahar Minjie Zhao Yrim M Diop Ermanno Candolfi Eric Marchioni Background: With the aim of discovering new natural active extracts against malaria